Microflora of upper parts of gastrointestinal tract during acute necrotizing pancreatitis

Abstract

Analysis of results of treatment of 153 patients with acute necrotizing pancreatitis has been performed. Small intestinal content at admission, fluid and necrotic collections were gathered for microbiological investigation. At 57,4% of patients 8 strains of gramm negative microorgamisms were identified from small intestine before operation. Similar microflore were cultivated from pathological foci at 57,4% of patients after operation. Minimal inhibitory concentration of rifaximin from < 0,25 till 8 µg/ml and ciprofloxacin from 0,25 till 1 µg/ml suppressed growth of 100% of isolated microorganisms in vitro.

Keywords

• acute pancreatitis
• bacterial colonization
• purulent septic complications