Molecules (Jul 2012)

<em></em>p-Cymene Protects Mice Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammatory Cell Activation

  • Haihua Feng,
  • Hongyu Li,
  • Qianchao Wu,
  • Ying Xiong,
  • Fang Liu,
  • Lanan Wassy Soromou,
  • Na Chen,
  • Guanghong Xie,
  • Guowen Liu

DOI
https://doi.org/10.3390/molecules17078159
Journal volume & issue
Vol. 17, no. 7
pp. 8159 – 8173

Abstract

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The objective of this study was to test the hypothesis that <em>p</em>-cymene can attenuate acute lung injury induced by lipopolysaccharide (LPS)<em> in vivo</em>. In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with <em>p</em>-cymene resulted in a significant reduction of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), lung water gain, inflammatory cell infiltration, lung tissue myeloperoxidase activity. In addition, <em>p</em>-cymene blocked the phosphorylation of IκBα protein and mitogen-activated protein kinases (MAPK) signaling pathway activation. Histopathologic examination of lung tissue indicated that <em>p</em>-cymene treatment markedly decreased focal thickening, congestion, pulmonary edema, and inflammatory cells infiltration. The results showed that <em>p</em>-cymene had a protective effect on LPS-induced ALI in mice.

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