Association between Anti-DENV IgM Serum Prevalence and CD11b Expression by Classical Monocytes in Obesity
Karine Beatriz Costa,
Bruna Caroline Chaves Garcia,
Marina Luiza Baêta Costa,
Yara Gomes Pena,
Eduardo Augusto Barbosa Figueiredo,
Marcelo Henrique Fernandes Ottoni,
Juliane Duarte Santos,
Vinícius de Oliveira Ottone,
Danilo Bretas de Oliveira,
Etel Rocha-Vieira
Affiliations
Karine Beatriz Costa
Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Universidade Federal dos Vales do Jequitinonha e Mucuri, Diamantina 39100-000, MG, Brazil
Bruna Caroline Chaves Garcia
Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Universidade Federal dos Vales do Jequitinonha e Mucuri, Diamantina 39100-000, MG, Brazil
Marina Luiza Baêta Costa
Laboratory of Exercise Biology and Immunometabolism, Centro Integrado de Pós-Graduação e Pesquisa em Saúde, Universidade Federal dos Vales do Jequitinonha e Mucuri, Diamantina 39100-000, MG, Brazil
Yara Gomes Pena
Laboratory of Exercise Biology and Immunometabolism, Centro Integrado de Pós-Graduação e Pesquisa em Saúde, Universidade Federal dos Vales do Jequitinonha e Mucuri, Diamantina 39100-000, MG, Brazil
Eduardo Augusto Barbosa Figueiredo
Laboratory of Exercise Biology and Immunometabolism, Centro Integrado de Pós-Graduação e Pesquisa em Saúde, Universidade Federal dos Vales do Jequitinonha e Mucuri, Diamantina 39100-000, MG, Brazil
Marcelo Henrique Fernandes Ottoni
Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal dos Vales do Jequitinonha e Mucuri, Diamantina 39100-000, MG, Brazil
Juliane Duarte Santos
Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Universidade Federal dos Vales do Jequitinonha e Mucuri, Diamantina 39100-000, MG, Brazil
Vinícius de Oliveira Ottone
Laboratory of Exercise Biology and Immunometabolism, Centro Integrado de Pós-Graduação e Pesquisa em Saúde, Universidade Federal dos Vales do Jequitinonha e Mucuri, Diamantina 39100-000, MG, Brazil
Danilo Bretas de Oliveira
Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Universidade Federal dos Vales do Jequitinonha e Mucuri, Diamantina 39100-000, MG, Brazil
Etel Rocha-Vieira
Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Universidade Federal dos Vales do Jequitinonha e Mucuri, Diamantina 39100-000, MG, Brazil
Dengue and obesity are currently highly prevalent conditions worldwide and the association between these two conditions may result in greater risk for DENV infection and disease severity. In this study the association between obesity and recent, inapparent dengue was investigated. Serum DENV IgM and NS1 were evaluated in 49 adult volunteers (15 lean and 34 individuals with obesity, according to body mass index), between September 2017 and June 2018. Adiposity, endocrine, metabolic, and immune data of the participants were also obtained. None of the study participants tested positive for the DENV NS1 antigen. DENV IgM was detected in 33.3% of the lean individuals, and in 44.1% of those with obesity; the presence of DENV IgM was not associated with body mass index (OR = 1.32, 95% CI = 0.59–2.98, p = 0.48). However, body fat index was higher in obese individuals who had recent inapparent dengue (14.7 ± 3.1 versus 12.7 ± 2.1 kg/m2, p = 0.04), as was the expression of CD11b by classical (CD14++CD16−) monocytes (1103.0 ± 311.3 versus 720.3 ± 281.1 mean fluoresce intensity). Our findings suggest an association between adiposity and recent inapparent dengue and the involvement of classical monocytes in this association.
