Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors

Xin Sun; Han Shan; Qibo Lin; Ziyan Chen; Dongxu Liu; Zhankai Liu; Kuan Peng; Zeyu Chen

doi:10.3390/mi13060946

Micromachines (Jun 2022)

Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors

Xin Sun,
Han Shan,
Qibo Lin,
Ziyan Chen,
Dongxu Liu,
Zhankai Liu,
Kuan Peng,
Zeyu Chen

Affiliations

Xin Sun: State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China
Han Shan: State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China
Qibo Lin: State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China
Ziyan Chen: State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China
Dongxu Liu: ULSO (Shanghai) Tech Co., Ltd., Shanghai 201821, China
Zhankai Liu: ULSO (Shanghai) Tech Co., Ltd., Shanghai 201821, China
Kuan Peng: Department of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, China
Zeyu Chen: State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China

DOI: https://doi.org/10.3390/mi13060946
Journal volume & issue: Vol. 13, no. 6
p. 946

Abstract

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Recently, indocyanine green (ICG), as an FDA-approved dye, has been widely used for phototherapy. It is essential to obtain information on the migration and aggregation of ICG in deep tissues. However, existing fluorescence imaging platforms are not able to obtain the structural information of the tissues. Here, we prepared ICG liposomes (ICG-Lips) and built a dual-wavelength photoacoustic computed tomography (PACT) system with piezoelectric ring-array transducer to image the aggregation of ICG-Lips in tumors to guide phototherapy. Visible 780 nm light excited the photoacoustic (PA) effects of the ICG-Lips and near-infrared 1064 nm light provided the imaging of the surrounding tissues. The aggregation of ICG-Lips within the tumor and the surrounding tissues was visualized by PACT in real time. This work indicates that PACT with piezoelectric ring-array transducer has great potential in the real-time monitoring of in vivo drug distribution.

Published in Micromachines

ISSN: 2072-666X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Mechanical engineering and machinery
Website: https://www.mdpi.com/journal/micromachines

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