BMC Pregnancy and Childbirth (Jul 2020)
Retrospective study 2005–2015 of all cases of fetal death occurred at ≥23 gestational weeks, in Friusli Venezia Giulia, Italy
- Lorenzo Monasta,
- Manuela Giangreco,
- Emanuele Ancona,
- Fabio Barbone,
- Elisa Bet,
- Pierino Boschian-Bailo,
- Giovanna Cacciaguerra,
- Angelo Cagnacci,
- Melania Canton,
- Maddalena Casarotto,
- Manola Comar,
- Simona Contardo,
- Michela De Agostini,
- Francesco De Seta,
- Giovanni Del Ben,
- Carla Di Loreto,
- Lorenza Driul,
- Stefano Facchin,
- Roberta Giornelli,
- Annalisa Ianni,
- Santo La Valle,
- Ambrogio Pietro Londero,
- Marciano Manfè,
- Gianpaolo Maso,
- Raffaela Mugittu,
- Monica Olivuzzi,
- Maria Orsaria,
- Vanna Pecile,
- Roberta Pinzano,
- Francesco Pirrone,
- Mariachiara Quadrifoglio,
- Giuseppe Ricci,
- Luca Ronfani,
- Tiziana Salviato,
- Elisa Sandrigo,
- Silvia Smiroldo,
- Alice Sorz,
- Tamara Stampalija,
- Marianela Urriza,
- Michele Vanin,
- Giuseppina Verardi,
- Salvatore Alberico
Affiliations
- Lorenzo Monasta
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Manuela Giangreco
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Emanuele Ancona
- SOC Ostetricia e Ginecologia, Policlinico S. Giorgio S.p.A
- Fabio Barbone
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Elisa Bet
- SC Ostetricia e Ginecologia Pordenone, Azienda per l’Assistenza Sanitaria N. 5 – Friuli Occidentale
- Pierino Boschian-Bailo
- SC Ostetricia e Ginecologia Gorizia – Monfalcone, Azienda per l’Assistenza Sanitaria N. 2 – Bassa Friulana-Isontina
- Giovanna Cacciaguerra
- SC Ostetricia e Ginecologia Palmanova – Latisana
- Angelo Cagnacci
- Azienda Sanitaria Universitaria Integrata di Udine
- Melania Canton
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Maddalena Casarotto
- SC Ostetricia e Ginecologia Pordenone, Azienda per l’Assistenza Sanitaria N. 5 – Friuli Occidentale
- Manola Comar
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Simona Contardo
- SC Ostetricia e Ginecologia San Vito – Spilimbergo, Azienda per l’Assistenza Sanitaria N. 5 – Friuli Occidentale
- Michela De Agostini
- SC Ostetricia e Ginecologia Palmanova – Latisana
- Francesco De Seta
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Giovanni Del Ben
- SOC Ostetricia e Ginecologia, Policlinico S. Giorgio S.p.A
- Carla Di Loreto
- Azienda Sanitaria Universitaria Integrata di Udine
- Lorenza Driul
- Azienda Sanitaria Universitaria Integrata di Udine
- Stefano Facchin
- SC Ostetricia e Ginecologia Palmanova – Latisana
- Roberta Giornelli
- SC Ostetricia e Ginecologia Gorizia – Monfalcone, Azienda per l’Assistenza Sanitaria N. 2 – Bassa Friulana-Isontina
- Annalisa Ianni
- SOC Ostetricia e Ginecologia San Daniele – Tolmezzo
- Santo La Valle
- SOC Ostetricia e Ginecologia, Policlinico S. Giorgio S.p.A
- Ambrogio Pietro Londero
- Azienda Sanitaria Universitaria Integrata di Udine
- Marciano Manfè
- SOC Ostetricia e Ginecologia, Policlinico S. Giorgio S.p.A
- Gianpaolo Maso
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Raffaela Mugittu
- SC Ostetricia e Ginecologia Gorizia – Monfalcone, Azienda per l’Assistenza Sanitaria N. 2 – Bassa Friulana-Isontina
- Monica Olivuzzi
- SOC Ostetricia e Ginecologia San Daniele – Tolmezzo
- Maria Orsaria
- Azienda Sanitaria Universitaria Integrata di Udine
- Vanna Pecile
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Roberta Pinzano
- SC Ostetricia e Ginecologia San Vito – Spilimbergo, Azienda per l’Assistenza Sanitaria N. 5 – Friuli Occidentale
- Francesco Pirrone
- SC Ostetricia e Ginecologia Pordenone, Azienda per l’Assistenza Sanitaria N. 5 – Friuli Occidentale
- Mariachiara Quadrifoglio
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Giuseppe Ricci
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Luca Ronfani
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Tiziana Salviato
- Università di Modena e Reggio Emilia
- Elisa Sandrigo
- SC Ostetricia e Ginecologia Gorizia – Monfalcone, Azienda per l’Assistenza Sanitaria N. 2 – Bassa Friulana-Isontina
- Silvia Smiroldo
- SOC Ostetricia e Ginecologia, Policlinico S. Giorgio S.p.A
- Alice Sorz
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Tamara Stampalija
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Marianela Urriza
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Michele Vanin
- SOC Ostetricia e Ginecologia San Daniele – Tolmezzo
- Giuseppina Verardi
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- Salvatore Alberico
- Institute for Maternal and Child Health – IRCCS Burlo Garofolo
- DOI
- https://doi.org/10.1186/s12884-020-03074-9
- Journal volume & issue
-
Vol. 20,
no. 1
pp. 1 – 10
Abstract
Abstract Background Intrauterine fetal death (IUFD) is a tragic event and, despite efforts to reduce rates, its incidence remains difficult to reduce. The objective of the present study was to examine the etiological factors that contribute to the main causes and conditions associated with IUFD, over an 11-year period in a region of North-East Italy (Friuli Venezia Giulia) for which reliable data in available. Methods Retrospective analysis of all 278 IUFD cases occurred between 2005 and 2015 in pregnancies with gestational age ≥ 23 weeks. Results The incidence of IUFD was 2.8‰ live births. Of these, 30% were small for gestational age (SGA), with immigrant women being significantly over-represented. The share of SGA reached 35% in cases in which a maternal of fetal pathological condition was present, and dropped to 28% in the absence of associated pathology. In 78 pregnancies (28%) no pathology was recorded that could justify IUFD. Of all IUFDs, 11% occurred during labor, and 72% occurred at a gestational age above 30 weeks. Conclusion The percentage of IUFD cases for which no possible cause can be identified is quite high. Only the adoption of evidence-based diagnostic protocols, with integrated immunologic, genetic and pathologic examinations, can help reduce this diagnostic gap, contributing to the prevention of future IUFDs.
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