Right ventricular size and function evaluated by various echocardiographic indices in dogs with pulmonary hypertension

Abstract

Abstract Background Three‐dimensional (3D) echocardiography and 2‐dimensional (2D) strain measurements of the right ventricle (RV) are important indices in humans with pulmonary hypertension (PH) and need further evaluation in dogs with PH. Objectives To evaluate various RV size and function indices in dogs with PH and to examine differences between pre‐ and postcapillary PH. Animals A total of 311 client‐owned dogs: 100 dogs with PH, 31 with postcapillary and 69 with precapillary PH, and 211 healthy control dogs. Methods Retro‐ and prospective, multicenter study. Size and function of the RV was determined using several indices, derived using dedicated RV software, including 3D RV end‐diastolic volume (EDVn), end‐systolic volume (ESVn), ejection fraction, 2D global and free wall RV longitudinal strain (RVLS), end‐diastolic area, end‐systolic area, fractional area change, tricuspid annular plane systolic excursion, and tissue Doppler imaging‐derived systolic myocardial velocity of the lateral tricuspid annulus (S′n). Results The EDVn (1.8 vs 2.5 mL/kg0.942, P < .01) and ESVn (0.8 vs 1.2 mL/kg0.962, P < .001) were significantly larger in the PH group compared to healthy controls. Free wall RVLS was decreased in dogs with severe PH compared to controls (−24% vs −29.6%, P < .001). Dogs with precapillary PH had worse RV systolic function than dogs with postcapillary PH. Conclusion Three‐dimensional echocardiography of the RV is a promising tool to detect RV changes in dogs with PH. Also, 2D strain measurements are able to detect decreased RV function and offer several advantages compared to conventional indices.

Keywords

• canine
• heart dimensions
• postcapillary
• precapillary
• speckle‐tracking echocardiography