Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5

Hui Zhang; Kun Chen; Qiuxiang Tan; Qiang Shao; Shuo Han; Chenhui Zhang; Cuiying Yi; Xiaojing Chu; Ya Zhu; Yechun Xu; Qiang Zhao; Beili Wu

doi:10.1038/s41467-021-24438-5

Nature Communications (Jul 2021)

Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5

Hui Zhang,
Kun Chen,
Qiuxiang Tan,
Qiang Shao,
Shuo Han,
Chenhui Zhang,
Cuiying Yi,
Xiaojing Chu,
Ya Zhu,
Yechun Xu,
Qiang Zhao,
Beili Wu

Affiliations

Hui Zhang: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Kun Chen: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Qiuxiang Tan: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Qiang Shao: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Shuo Han: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Chenhui Zhang: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Cuiying Yi: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Xiaojing Chu: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Ya Zhu: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yechun Xu: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Qiang Zhao: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Beili Wu: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-021-24438-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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The chemokine receptor CCR5 plays multiple roles in the immune system. Here, structures of Gi1 protein-coupled CCR5 with or without a chemokine bound and of the CCR5- chemokine MIP-1 α complex offer insight into the distinct binding modes of the ligands and into the mechanism of CCR5 activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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