Hypertension in Pregnancy (Oct 2019)

Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction

  • Manouk L. E. Hendrix,
  • Kirsten C. M. Palm,
  • Sander M. J. Van Kuijk,
  • Otto Bekers,
  • Marc E. A. Spaanderman,
  • Judith A. P. Bons,
  • Salwan Al-Nasiry

DOI
https://doi.org/10.1080/10641955.2019.1668948
Journal volume & issue
Vol. 38, no. 4
pp. 268 – 277

Abstract

Read online

Objective: To evaluate longitudinal changes of angiogenic biomarkers in early- (EO-PD) versus late-onset (LO-PD) placental dysfunction. Methods: Serum PlGF and sFlt-1 measured at different intervals in EO-PD (n= 43), LO-PD (n= 31) and controls (n = 133). Results: sFlt-1/PlGF ratio was higher at 16 weeks (30.6 vs 17.5), 20 weeks (29.3 vs 8.9) and 30 weeks (16.6 vs 6.7) in EO-PD vs controls (all p< 0.05), but not in LO-PD. Longitudinal changes for all intervals had higher AUC than single measurements. Conclusion: Longitudinal biomarker change between 12 and 30 weeks could improve prediction of EO-PD compared to single measurements.

Keywords