Nature Communications (Dec 2018)
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
- Carlo C. Campa,
- Rangel L. Silva,
- Jean P. Margaria,
- Tracey Pirali,
- Matheus S. Mattos,
- Lucas R. Kraemer,
- Diego C. Reis,
- Giorgio Grosa,
- Francesca Copperi,
- Eduardo M. Dalmarco,
- Roberto C. P. Lima-Júnior,
- Silvio Aprile,
- Valentina Sala,
- Federica Dal Bello,
- Douglas Silva Prado,
- Jose Carlos Alves-Filho,
- Claudio Medana,
- Geovanni D. Cassali,
- Gian Cesare Tron,
- Mauro M. Teixeira,
- Elisa Ciraolo,
- Remo C. Russo,
- Emilio Hirsch
Affiliations
- Carlo C. Campa
- Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino
- Rangel L. Silva
- Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino
- Jean P. Margaria
- Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino
- Tracey Pirali
- Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale “A. Avogadro”
- Matheus S. Mattos
- Laboratory of Pulmonary Immunology and Mechanics, Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais/UFMG
- Lucas R. Kraemer
- Laboratory of Pulmonary Immunology and Mechanics, Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais/UFMG
- Diego C. Reis
- Laboratory of Pulmonary Immunology and Mechanics, Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais/UFMG
- Giorgio Grosa
- Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale “A. Avogadro”
- Francesca Copperi
- Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino
- Eduardo M. Dalmarco
- Department of Clinical Analysis, Universidade Federal de Santa Catarina/UFSC
- Roberto C. P. Lima-Júnior
- Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino
- Silvio Aprile
- Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale “A. Avogadro”
- Valentina Sala
- Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino
- Federica Dal Bello
- Department of Molecular Biotechnology and Health Sciences, Mass Spectrometry Unit, University of Torino
- Douglas Silva Prado
- Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo
- Jose Carlos Alves-Filho
- Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo
- Claudio Medana
- Department of Molecular Biotechnology and Health Sciences, Mass Spectrometry Unit, University of Torino
- Geovanni D. Cassali
- Laboratory of Comparative Pathology, Department of General Pathology Institute of Biological Sciences, Universidade Federal de Minas Gerais/UFMG
- Gian Cesare Tron
- Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale “A. Avogadro”
- Mauro M. Teixeira
- Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais/UFMG
- Elisa Ciraolo
- Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino
- Remo C. Russo
- Laboratory of Pulmonary Immunology and Mechanics, Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais/UFMG
- Emilio Hirsch
- Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino
- DOI
- https://doi.org/10.1038/s41467-018-07698-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Activation of PI3K plays a role in pulmonary inflammation. Here, the authors develop a drug inhibitor of PI3K, and show that it inhibits lung inflammation and damage in mouse models of asthma and lung fibrosis.
