Nature Communications (Jun 2020)
The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
- Bin Zhu,
- Maria Luana Poeta,
- Manuela Costantini,
- Tongwu Zhang,
- Jianxin Shi,
- Steno Sentinelli,
- Wei Zhao,
- Vincenzo Pompeo,
- Maurizio Cardelli,
- Boian S. Alexandrov,
- Burcak Otlu,
- Xing Hua,
- Kristine Jones,
- Seth Brodie,
- Malgorzata Ewa Dabrowska,
- Jorge R. Toro,
- Meredith Yeager,
- Mingyi Wang,
- Belynda Hicks,
- Ludmil B. Alexandrov,
- Kevin M. Brown,
- David C. Wedge,
- Stephen Chanock,
- Vito Michele Fazio,
- Michele Gallucci,
- Maria Teresa Landi
Affiliations
- Bin Zhu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Maria Luana Poeta
- Department of Bioscience, Biotechnology and Biopharmaceutics, University of Bari
- Manuela Costantini
- Department of Bioscience, Biotechnology and Biopharmaceutics, University of Bari
- Tongwu Zhang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Jianxin Shi
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Steno Sentinelli
- Department of Pathology, “Regina Elena” National Cancer Institute
- Wei Zhao
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Vincenzo Pompeo
- Department of Urology, “Regina Elena” National Cancer Institute
- Maurizio Cardelli
- Advanced Technology Center for Aging Research, IRCCS INRCA
- Boian S. Alexandrov
- Theoretical Division, Los Alamos National Laboratory
- Burcak Otlu
- Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego
- Xing Hua
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Kristine Jones
- Cancer Genomics Research Laboratory (CGR), Frederick National Laboratory for Cancer Research
- Seth Brodie
- Cancer Genomics Research Laboratory (CGR), Frederick National Laboratory for Cancer Research
- Malgorzata Ewa Dabrowska
- Department of Pathology, “Regina Elena” National Cancer Institute
- Jorge R. Toro
- Washington, DC Veteran Affairs Medical Center
- Meredith Yeager
- Cancer Genomics Research Laboratory (CGR), Frederick National Laboratory for Cancer Research
- Mingyi Wang
- Cancer Genomics Research Laboratory (CGR), Frederick National Laboratory for Cancer Research
- Belynda Hicks
- Cancer Genomics Research Laboratory (CGR), Frederick National Laboratory for Cancer Research
- Ludmil B. Alexandrov
- Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego
- Kevin M. Brown
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- David C. Wedge
- Big Data Institute
- Stephen Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Vito Michele Fazio
- Laboratory of Molecular Medicine and Biotechnology, University Campus Bio-Medico of Rome
- Michele Gallucci
- Department of Urology, “Regina Elena” National Cancer Institute
- Maria Teresa Landi
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- DOI
- https://doi.org/10.1038/s41467-020-16546-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Many tumours are heterogenous, which calls into question whether multiple biopsies are required to accurately assess the cancer. Here, the authors show that papillary renal cell carcinoma is clonal in nature, suggesting that in this cancer one biopsy is sufficient for diagnosis and molecular analyses.
