Nature Communications (Nov 2018)
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
- David L. Duffy,
- Gu Zhu,
- Xin Li,
- Marianna Sanna,
- Mark M. Iles,
- Leonie C. Jacobs,
- David M. Evans,
- Seyhan Yazar,
- Jonathan Beesley,
- Matthew H. Law,
- Peter Kraft,
- Alessia Visconti,
- John C. Taylor,
- Fan Liu,
- Margaret J. Wright,
- Anjali K. Henders,
- Lisa Bowdler,
- Dan Glass,
- M. Arfan Ikram,
- André G. Uitterlinden,
- Pamela A. Madden,
- Andrew C. Heath,
- Elliot C. Nelson,
- Adele C. Green,
- Stephen Chanock,
- Jennifer H. Barrett,
- Matthew A. Brown,
- Nicholas K. Hayward,
- Stuart MacGregor,
- Richard A. Sturm,
- Alex W. Hewitt,
- Melanoma GWAS Consortium,
- Manfred Kayser,
- David J. Hunter,
- Julia A. Newton Bishop,
- Timothy D. Spector,
- Grant W. Montgomery,
- David A. Mackey,
- George Davey Smith,
- Tamar E. Nijsten,
- D. Timothy Bishop,
- Veronique Bataille,
- Mario Falchi,
- Jiali Han,
- Nicholas G. Martin
Affiliations
- David L. Duffy
- QIMR Berghofer Medical Research Institute
- Gu Zhu
- QIMR Berghofer Medical Research Institute
- Xin Li
- Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indiana University
- Marianna Sanna
- Department of Twin Research & Genetic Epidemiology, St Thomas Hospital Campus, Kings College
- Mark M. Iles
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- Leonie C. Jacobs
- Department of Dermatology, Erasmus MC, University Medical Centre Rotterdam
- David M. Evans
- MRC Integrative Epidemiology Unit, University of Bristol
- Seyhan Yazar
- Centre for Ophthalmology and Vision Science, University of Western Australia and the Lions Eye Institute
- Jonathan Beesley
- QIMR Berghofer Medical Research Institute
- Matthew H. Law
- QIMR Berghofer Medical Research Institute
- Peter Kraft
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Alessia Visconti
- Department of Twin Research & Genetic Epidemiology, St Thomas Hospital Campus, Kings College
- John C. Taylor
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- Fan Liu
- Department of Genetic Identification, Erasmus MC, University Medical Centre Rotterdam
- Margaret J. Wright
- QIMR Berghofer Medical Research Institute
- Anjali K. Henders
- QIMR Berghofer Medical Research Institute
- Lisa Bowdler
- QIMR Berghofer Medical Research Institute
- Dan Glass
- Department of Twin Research & Genetic Epidemiology, St Thomas Hospital Campus, Kings College
- M. Arfan Ikram
- Department of Epidemiology, Erasmus MC
- André G. Uitterlinden
- Department of Epidemiology, Erasmus MC
- Pamela A. Madden
- Department of Psychiatry, Washington University School of Medicine
- Andrew C. Heath
- Department of Psychiatry, Washington University School of Medicine
- Elliot C. Nelson
- Department of Psychiatry, Washington University School of Medicine
- Adele C. Green
- QIMR Berghofer Medical Research Institute
- Stephen Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Jennifer H. Barrett
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- Matthew A. Brown
- University of Queensland Diamantina Institute, Translational Research Institute
- Nicholas K. Hayward
- QIMR Berghofer Medical Research Institute
- Stuart MacGregor
- QIMR Berghofer Medical Research Institute
- Richard A. Sturm
- Dermatology Research Centre, University of Queensland Diamantina Institute, Translational Research Institute
- Alex W. Hewitt
- Centre for Ophthalmology and Vision Science, University of Western Australia and the Lions Eye Institute
- Melanoma GWAS Consortium
- Manfred Kayser
- Department of Genetic Identification, Erasmus MC, University Medical Centre Rotterdam
- David J. Hunter
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Julia A. Newton Bishop
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- Timothy D. Spector
- Department of Twin Research & Genetic Epidemiology, St Thomas Hospital Campus, Kings College
- Grant W. Montgomery
- QIMR Berghofer Medical Research Institute
- David A. Mackey
- Centre for Ophthalmology and Vision Science, University of Western Australia and the Lions Eye Institute
- George Davey Smith
- MRC Integrative Epidemiology Unit, University of Bristol
- Tamar E. Nijsten
- Department of Dermatology, Erasmus MC, University Medical Centre Rotterdam
- D. Timothy Bishop
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- Veronique Bataille
- Department of Twin Research & Genetic Epidemiology, St Thomas Hospital Campus, Kings College
- Mario Falchi
- Department of Twin Research & Genetic Epidemiology, St Thomas Hospital Campus, Kings College
- Jiali Han
- Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indiana University
- Nicholas G. Martin
- QIMR Berghofer Medical Research Institute
- DOI
- https://doi.org/10.1038/s41467-018-06649-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Melanocytic nevus count is associated with melanoma risk. In this study, a meta-analysis of 11 nevus GWAS studies identifies novel SNPs in KITLG and 9q32, and bivariate analysis with melanoma GWAS meta-analysis reveals that most nevus genes affect melanoma risk, while melanoma risk loci do not alter the nevus count.
