Recruitment of a splicing factor to the nuclear lamina for its inactivation

Karen Vester; Marco Preußner; Nicole Holton; Suihan Feng; Carsten Schultz; Florian Heyd; Markus C. Wahl

doi:10.1038/s42003-022-03689-y

Communications Biology (Jul 2022)

Recruitment of a splicing factor to the nuclear lamina for its inactivation

Karen Vester,
Marco Preußner,
Nicole Holton,
Suihan Feng,
Carsten Schultz,
Florian Heyd,
Markus C. Wahl

Affiliations

Karen Vester: Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry
Marco Preußner: Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of RNA Biochemistry
Nicole Holton: Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry
Suihan Feng: Oregon Health and Science University, Department of Chemical Physiology and Biochemistry
Carsten Schultz: Oregon Health and Science University, Department of Chemical Physiology and Biochemistry
Florian Heyd: Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of RNA Biochemistry
Markus C. Wahl: Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry

DOI: https://doi.org/10.1038/s42003-022-03689-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

Read online

Through the use of a reversible chemical dimerizer, the splicing factor PRPF38A is re-localized to the nuclear lamina, paving the way for a systematic analysis of spatio-temporal splicing regulation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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