Research progress on the role of glutamine metabolism-related proteins in tumor metastasis

Abstract

Tumor metastasis is closely related to high mortality rate of cancer. It is well known that glutamine plays an important role in the malignant progression of cancer. Notably, as an important carbon and nitrogen donor, glutamine has been found to be closely related to tumor metastasis in recent years. Glutamine is not only involved in regulating the proliferation of tumor cells, but is also closely related to the migration and invasion of tumor cells. Furthermore, various enzymes along with transporters in the metabolism of glutamine are involved in the process of tumor metastasis through different signaling pathways. This review provided a summary of the role of glutamine in tumor metastasis in recent years and proposed therapeutic targets to provide new strategies for the clinical treatment of tumor metastases.

Keywords

• |glutamine metabolism|tumor metastasis|epithelial-mesenchymal transition|targeted therapy