Synthesis and Characterization of Some New Oxazolidinone and Thiazolidinone Derivatives Via Reaction of Schiff Bases Derived from some Amino Acids

Abstract

New derivatives of 2,3- substituted – oxazolidinone and thiazolidinone were synthesized by cycloaddition reaction of glycolic acid and thioglycolic to various Schiff bases derived from some commercially available amino acids in anhydrous 1,4-dioxane under dry and reflux conditions. Schiff's bases were synthesized by refluxing various amino acids with aromatic aldehydes and ketones with few drops of glacial acetic acid as a catalyst in absolute methanol. The products were isolated, purified and characterized by their melting point , FT-IR and 1HNMR spectra and C.H.N analysis.

Keywords

• oxazolidinone
• thiazolidinone
• glycolic acid
• thioglycolic
• imines