Frontiers in Physiology (Jan 2014)

Atrial Fibrillation and MicroRNAs

  • Gaetano eSantulli,
  • Guido eIACCARINO,
  • Nicola eDe Luca,
  • Bruno eTrimarco,
  • Gianluigi eCondorelli

DOI
https://doi.org/10.3389/fphys.2014.00015
Journal volume & issue
Vol. 5

Abstract

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Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This article represents a systematic and updated appraisal of the studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.

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