Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7

Lili Gu; David Casserly; Gareth Brady; Susan Carpenter; Adrian P. Bracken; Katherine A. Fitzgerald; Leonie Unterholzner; Andrew G. Bowie

doi:10.1038/s41467-021-27701-x

Nature Communications (Jan 2022)

Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7

Lili Gu,
David Casserly,
Gareth Brady,
Susan Carpenter,
Adrian P. Bracken,
Katherine A. Fitzgerald,
Leonie Unterholzner,
Andrew G. Bowie

Affiliations

Lili Gu: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
David Casserly: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
Gareth Brady: School of Medicine, Trinity College Dublin
Susan Carpenter: Division of Innate Immunity, University of Massachusetts Chan Medical School
Adrian P. Bracken: Smurfit Institute of Genetics, Trinity College Dublin
Katherine A. Fitzgerald: Division of Innate Immunity, University of Massachusetts Chan Medical School
Leonie Unterholzner: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
Andrew G. Bowie: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin

DOI: https://doi.org/10.1038/s41467-021-27701-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

The interferon response is a critical component of the innate immune response. Here the authors implicate MNDA in the regulation of type I interferon responses to pathogen infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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