Nature Communications (Sep 2019)
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24
- Tao Yu,
- Shucheng Gan,
- Qingchen Zhu,
- Dongfang Dai,
- Ni Li,
- Hui Wang,
- Xiaosong Chen,
- Dan Hou,
- Yan Wang,
- Qiang Pan,
- Jing Xu,
- Xingli Zhang,
- Junli Liu,
- Siyu Pei,
- Chao Peng,
- Ping Wu,
- Simona Romano,
- Chaoming Mao,
- Mingzhu Huang,
- Xiaodong Zhu,
- Kunwei Shen,
- Jun Qin,
- Yichuan Xiao
Affiliations
- Tao Yu
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Shucheng Gan
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Qingchen Zhu
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Dongfang Dai
- Institute of Oncology and Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University
- Ni Li
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Hui Wang
- Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Xiaosong Chen
- Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Dan Hou
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Yan Wang
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Qiang Pan
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Jing Xu
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Xingli Zhang
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Junli Liu
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Siyu Pei
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Chao Peng
- National Facility for Protein Science in Shanghai, Zhangjiang Lab
- Ping Wu
- National Facility for Protein Science in Shanghai, Zhangjiang Lab
- Simona Romano
- Department of Molecular Medicine and Medical Biotechnology, University of Naples, Federico II
- Chaoming Mao
- Institute of Oncology and Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University
- Mingzhu Huang
- Department of Medical Oncology, Fudan University Shanghai Cancer Center
- Xiaodong Zhu
- Department of Medical Oncology, Fudan University Shanghai Cancer Center
- Kunwei Shen
- Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Jun Qin
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Yichuan Xiao
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-019-12384-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Stat6 promotes M2 macrophage polarization. Here the authors characterize Trim24-CBP-Stat6 circuit regulating M2 macrophage polarization via Stat6 acetylation, and show it contributes to pro-tumorigenic macrophage activity in mice.
