Nature Communications (Mar 2020)
Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
- Ellen Brenner,
- Barbara F. Schörg,
- Fatima Ahmetlić,
- Thomas Wieder,
- Franz Joachim Hilke,
- Nadine Simon,
- Christopher Schroeder,
- German Demidov,
- Tanja Riedel,
- Birgit Fehrenbacher,
- Martin Schaller,
- Andrea Forschner,
- Thomas Eigentler,
- Heike Niessner,
- Tobias Sinnberg,
- Katharina S. Böhm,
- Nadine Hömberg,
- Heidi Braumüller,
- Daniel Dauch,
- Stefan Zwirner,
- Lars Zender,
- Dominik Sonanini,
- Albert Geishauser,
- Jürgen Bauer,
- Martin Eichner,
- Katja J. Jarick,
- Andreas Beilhack,
- Saskia Biskup,
- Dennis Döcker,
- Dirk Schadendorf,
- Leticia Quintanilla-Martinez,
- Bernd J. Pichler,
- Manfred Kneilling,
- Ralph Mocikat,
- Martin Röcken
Affiliations
- Ellen Brenner
- Department of Dermatology, University of Tübingen
- Barbara F. Schörg
- Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen
- Fatima Ahmetlić
- Institut für Molekulare Immunologie, Helmholtz-Zentrum München
- Thomas Wieder
- Department of Dermatology, University of Tübingen
- Franz Joachim Hilke
- Institute of Medical Genetics and Applied Genomics, University of Tübingen
- Nadine Simon
- Department of Dermatology, University of Tübingen
- Christopher Schroeder
- Institute of Medical Genetics and Applied Genomics, University of Tübingen
- German Demidov
- Institute of Medical Genetics and Applied Genomics, University of Tübingen
- Tanja Riedel
- Institut für Molekulare Immunologie, Helmholtz-Zentrum München
- Birgit Fehrenbacher
- Department of Dermatology, University of Tübingen
- Martin Schaller
- Department of Dermatology, University of Tübingen
- Andrea Forschner
- Department of Dermatology, University of Tübingen
- Thomas Eigentler
- Department of Dermatology, University of Tübingen
- Heike Niessner
- Department of Dermatology, University of Tübingen
- Tobias Sinnberg
- Department of Dermatology, University of Tübingen
- Katharina S. Böhm
- Department of Dermatology, University of Tübingen
- Nadine Hömberg
- Institut für Molekulare Immunologie, Helmholtz-Zentrum München
- Heidi Braumüller
- Department of Dermatology, University of Tübingen
- Daniel Dauch
- Department of Medical Oncology and Pneumology, University Hospital Tübingen
- Stefan Zwirner
- Department of Medical Oncology and Pneumology, University Hospital Tübingen
- Lars Zender
- Department of Medical Oncology and Pneumology, University Hospital Tübingen
- Dominik Sonanini
- Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen
- Albert Geishauser
- Institut für Molekulare Immunologie, Helmholtz-Zentrum München
- Jürgen Bauer
- Department of Dermatology, University of Tübingen
- Martin Eichner
- Institute of Clinical Epidemiology and Applied Biometry, University of Tübingen
- Katja J. Jarick
- Department of Medicine II, Würzburg University
- Andreas Beilhack
- Department of Medicine II, Würzburg University
- Saskia Biskup
- Cluster of Excellence iFIT (EXC 2180) “Image Guided and Functionally Instructed Tumor Therapies”
- Dennis Döcker
- Department of Dermatology, University of Tübingen
- Dirk Schadendorf
- German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ)
- Leticia Quintanilla-Martinez
- Cluster of Excellence iFIT (EXC 2180) “Image Guided and Functionally Instructed Tumor Therapies”
- Bernd J. Pichler
- Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen
- Manfred Kneilling
- Department of Dermatology, University of Tübingen
- Ralph Mocikat
- Institut für Molekulare Immunologie, Helmholtz-Zentrum München
- Martin Röcken
- Department of Dermatology, University of Tübingen
- DOI
- https://doi.org/10.1038/s41467-020-14987-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
The growth of cancer cells can be stably arrested by cytokine-induced senescence. Here, the authors show that cancers with defects in senescence-inducing cell cycle regulator pathways are resistant to immune checkpoint blockade.
