Nature Communications (Jun 2021)

Designed and biologically active protein lattices

  • Shih-Ting Wang,
  • Brian Minevich,
  • Jianfang Liu,
  • Honghu Zhang,
  • Dmytro Nykypanchuk,
  • James Byrnes,
  • Wu Liu,
  • Lev Bershadsky,
  • Qun Liu,
  • Tong Wang,
  • Gang Ren,
  • Oleg Gang

DOI
https://doi.org/10.1038/s41467-021-23966-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Organising proteins in 2D and 3D is needed to develop complex bimolecular materials for a range of applications. Here, the authors report the encapsulation of ferritin and apoferritin in DNA-based voxels with programmed assembly to generate both 2D and 3D protein lattices and demonstrate the retention of protein function.