The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

Ting Yuan; Karthika Annamalai; Shruti Naik; Blaz Lupse; Shirin Geravandi; Anasua Pal; Aleksandra Dobrowolski; Jaee Ghawali; Marina Ruhlandt; Kanaka Durga Devi Gorrepati; Zahra Azizi; Dae-Sik Lim; Kathrin Maedler; Amin Ardestani

doi:10.1038/s41467-021-25145-x

Nature Communications (Aug 2021)

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

Ting Yuan,
Karthika Annamalai,
Shruti Naik,
Blaz Lupse,
Shirin Geravandi,
Anasua Pal,
Aleksandra Dobrowolski,
Jaee Ghawali,
Marina Ruhlandt,
Kanaka Durga Devi Gorrepati,
Zahra Azizi,
Dae-Sik Lim,
Kathrin Maedler,
Amin Ardestani

Affiliations

Ting Yuan: Centre for Biomolecular Interactions Bremen, University of Bremen
Karthika Annamalai: Centre for Biomolecular Interactions Bremen, University of Bremen
Shruti Naik: Centre for Biomolecular Interactions Bremen, University of Bremen
Blaz Lupse: Centre for Biomolecular Interactions Bremen, University of Bremen
Shirin Geravandi: Centre for Biomolecular Interactions Bremen, University of Bremen
Anasua Pal: Centre for Biomolecular Interactions Bremen, University of Bremen
Aleksandra Dobrowolski: Centre for Biomolecular Interactions Bremen, University of Bremen
Jaee Ghawali: Centre for Biomolecular Interactions Bremen, University of Bremen
Marina Ruhlandt: Centre for Biomolecular Interactions Bremen, University of Bremen
Kanaka Durga Devi Gorrepati: Centre for Biomolecular Interactions Bremen, University of Bremen
Zahra Azizi: Centre for Biomolecular Interactions Bremen, University of Bremen
Dae-Sik Lim: Department of Biological Sciences, KAIST 291 Daehak-ro, Yuseong-gu
Kathrin Maedler: Centre for Biomolecular Interactions Bremen, University of Bremen
Amin Ardestani: Centre for Biomolecular Interactions Bremen, University of Bremen

DOI: https://doi.org/10.1038/s41467-021-25145-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and autophagic flux suppression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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