Nature Communications (Apr 2016)
Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
Abstract
Although IFNγ is a Th1 signature cytokine and is repressed in Th2 cells, it is reactivated in a subset of memory Th2 cells. Here the authors show that Hdac2 is released from Gata3 by Akt-mediated phosphorylation, leading to transcriptional derepression of Tbx21 and IFNγin these cells.