Genome-wide copy number variant data for inflammatory bowel disease in a caucasian population
Svetlana Frenkel,
Charles N. Bernstein,
Yong Won Jin,
Michael Sargent,
Qin Kuang,
Wenxin Jiang,
John Wei,
Bhooma Thiruvahindrapuram,
Stephen W. Scherer,
Pingzhao Hu
Affiliations
Svetlana Frenkel
Department of Biochemistry and Medical Genetics, The George and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, MB, Canada
Charles N. Bernstein
Department of Internal Medicine, The University of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada
Yong Won Jin
Department of Biochemistry and Medical Genetics, The George and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, MB, Canada
Michael Sargent
Department of Internal Medicine, The University of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada
Qin Kuang
Department of Biochemistry and Medical Genetics, The George and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, MB, Canada
Wenxin Jiang
Department of Biochemistry and Medical Genetics, The George and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, MB, Canada; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
John Wei
The Centre for Applied Genomics, Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada
Bhooma Thiruvahindrapuram
The Centre for Applied Genomics, Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada
Stephen W. Scherer
The Centre for Applied Genomics, Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
Pingzhao Hu
Department of Biochemistry and Medical Genetics, The George and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, MB, Canada; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Department of Electrical and Computer Engineering, University of Manitoba, Winnipeg, MB, Canada; Corresponding author. Department of Biochemistry and Medical Genetics, Room 308 - Basic Medical Sciences Building, 745 Bannatyne Avenue, University of Manitoba, Winnipeg, Manitoba, R3E 0J9, Canada.
Genome-wide copy-number association studies offer new opportunities to identify the mechanisms underlying complex diseases, including chronic inflammatory, psychiatric disorders and others. We have used genotyping microarrays to analyse the copy-number variants (CNVs) from 243 Caucasian individuals with Inflammatory Bowel Disease (IBD). The CNV data was obtained by using multiple quality control measures and merging the results of three different CNV detection algorithms: PennCNV, iPattern, and QuantiSNP. The final dataset contains 4,402 CNVs detected by two or three algorithms independently with high confidence. This paper provides a detailed description of the data generation and quality control steps. For further interpretation of the data presented in this article, please see the research article entitled ‘Copy number variation-based gene set analysis reveals cytokine signalling pathways associated with psychiatric comorbidity in patients with inflammatory bowel disease’.
