Nature Communications (Nov 2018)
Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions
- Thomas Philipp Hoernes,
- Klaus Faserl,
- Michael Andreas Juen,
- Johannes Kremser,
- Catherina Gasser,
- Elisabeth Fuchs,
- Xinying Shi,
- Aaron Siewert,
- Herbert Lindner,
- Christoph Kreutz,
- Ronald Micura,
- Simpson Joseph,
- Claudia Höbartner,
- Eric Westhof,
- Alexander Hüttenhofer,
- Matthias David Erlacher
Affiliations
- Thomas Philipp Hoernes
- Division of Genomics and RNomics, Biocenter, Medical University of Innsbruck
- Klaus Faserl
- Division of Clinical Biochemistry, Biocenter, Medical University of Innsbruck
- Michael Andreas Juen
- Institute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck
- Johannes Kremser
- Institute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck
- Catherina Gasser
- Institute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck
- Elisabeth Fuchs
- Institute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck
- Xinying Shi
- Department of Chemistry and Biochemistry, University of California at San Diego
- Aaron Siewert
- Institute of Organic Chemistry, University of Würzburg, Am Hubland
- Herbert Lindner
- Division of Clinical Biochemistry, Biocenter, Medical University of Innsbruck
- Christoph Kreutz
- Institute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck
- Ronald Micura
- Institute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck
- Simpson Joseph
- Department of Chemistry and Biochemistry, University of California at San Diego
- Claudia Höbartner
- Institute of Organic Chemistry, University of Würzburg, Am Hubland
- Eric Westhof
- Architecture and Reactivity of RNA, Institute of Molecular and Cellular Biology of the CNRS UPR9002/University of Strasbourg
- Alexander Hüttenhofer
- Division of Genomics and RNomics, Biocenter, Medical University of Innsbruck
- Matthias David Erlacher
- Division of Genomics and RNomics, Biocenter, Medical University of Innsbruck
- DOI
- https://doi.org/10.1038/s41467-018-07321-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
The recognition of the mRNA codon by the tRNA anticodon is crucial for protein synthesis. Here the authors introduce non-standard nucleotides in bacterial and eukaryotic mRNA to reveal the minimal hydrogen bond requirement of codon-anticodon interaction for efficient and accurate translation.
