Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Marlena S. Fejzo; Olga V. Sazonova; J. Fah Sathirapongsasuti; Ingileif B. Hallgrímsdóttir; Vladimir Vacic; Kimber W. MacGibbon; Frederic P. Schoenberg; Nicholas Mancuso; Dennis J. Slamon; Patrick M. Mullin; 23andMe Research Team

doi:10.1038/s41467-018-03258-0

Nature Communications (Mar 2018)

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Marlena S. Fejzo,
Olga V. Sazonova,
J. Fah Sathirapongsasuti,
Ingileif B. Hallgrímsdóttir,
Vladimir Vacic,
Kimber W. MacGibbon,
Frederic P. Schoenberg,
Nicholas Mancuso,
Dennis J. Slamon,
Patrick M. Mullin,
23andMe Research Team

Affiliations

Marlena S. Fejzo: Division of Hematology-Oncology, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles
Olga V. Sazonova: 23andMe, Inc.
J. Fah Sathirapongsasuti: 23andMe, Inc.
Ingileif B. Hallgrímsdóttir: 23andMe, Inc.
Vladimir Vacic: 23andMe, Inc.
Kimber W. MacGibbon: Hyperemesis Education and Research Foundation
Frederic P. Schoenberg: Department of Statistics, University of California, Los Angeles
Nicholas Mancuso: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles
Dennis J. Slamon: Division of Hematology-Oncology, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles
Patrick M. Mullin: Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California
23andMe Research Team

DOI: https://doi.org/10.1038/s41467-018-03258-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

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Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting associated with unfavourable outcomes during pregnancy. Here, Fejzo et al. perform genome-wide scans for HG and pregnancy nausea and vomiting and identify genetic associations at two loci implicating the genes GDF15 and IGFBP7.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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