Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors

Marie E Jönsson; Per Ludvik Brattås; Charlotte Gustafsson; Rebecca Petri; David Yudovich; Karolina Pircs; Shana Verschuere; Sofia Madsen; Jenny Hansson; Jonas Larsson; Robert Månsson; Alexander Meissner; Johan Jakobsson

doi:10.1038/s41467-019-11150-8

Nature Communications (Jul 2019)

Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors

Marie E Jönsson,
Per Ludvik Brattås,
Charlotte Gustafsson,
Rebecca Petri,
David Yudovich,
Karolina Pircs,
Shana Verschuere,
Sofia Madsen,
Jenny Hansson,
Jonas Larsson,
Robert Månsson,
Alexander Meissner,
Johan Jakobsson

Affiliations

Marie E Jönsson: Wallenberg Neuroscience Center and Lund Stem Cell Center, Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, BMC A11, Lund University
Per Ludvik Brattås: Wallenberg Neuroscience Center and Lund Stem Cell Center, Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, BMC A11, Lund University
Charlotte Gustafsson: Center for Hematology and Regenerative Medicine Huddinge, Karolinska Institute
Rebecca Petri: Wallenberg Neuroscience Center and Lund Stem Cell Center, Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, BMC A11, Lund University
David Yudovich: Division of Molecular Medicine and Gene Therapy, Department of Laboratory Medicine and Lund Stem Cell Center, BMC A12, Lund University
Karolina Pircs: Wallenberg Neuroscience Center and Lund Stem Cell Center, Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, BMC A11, Lund University
Shana Verschuere: Wallenberg Neuroscience Center and Lund Stem Cell Center, Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, BMC A11, Lund University
Sofia Madsen: Wallenberg Neuroscience Center and Lund Stem Cell Center, Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, BMC A11, Lund University
Jenny Hansson: Laboratory of Proteomic Hematology, Department of Laboratory Medicine and Lund Stem Cell Center, BMC B12, Lund University
Jonas Larsson: Division of Molecular Medicine and Gene Therapy, Department of Laboratory Medicine and Lund Stem Cell Center, BMC A12, Lund University
Robert Månsson: Center for Hematology and Regenerative Medicine Huddinge, Karolinska Institute
Alexander Meissner: Department of Genome Regulation, Max Planck Institute for Molecular Genetics
Johan Jakobsson: Wallenberg Neuroscience Center and Lund Stem Cell Center, Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, BMC A11, Lund University

DOI: https://doi.org/10.1038/s41467-019-11150-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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DNA methylation plays an important role in silencing transposable elements. Here the authors find that loss of DNMT1 and DNA methylation leads to transcriptional activation and chromatin remodelling of evolutionarily young—hominoid-specific —LINE-1 elements which then act as alternative promoters for neuronal genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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