Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA

Leandro José de Assis; Lilian Pereira Silva; Ozgur Bayram; Paul Dowling; Olaf Kniemeyer; Thomas Krüger; Axel A. Brakhage; Yingying Chen; Liguo Dong; Kaeling Tan; Koon Ho Wong; Laure N. A. Ries; Gustavo H. Goldman

doi:10.1128/mBio.03146-20

mBio (Feb 2021)

Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA

Leandro José de Assis,
Lilian Pereira Silva,
Ozgur Bayram,
Paul Dowling,
Olaf Kniemeyer,
Thomas Krüger,
Axel A. Brakhage,
Yingying Chen,
Liguo Dong,
Kaeling Tan,
Koon Ho Wong,
Laure N. A. Ries,
Gustavo H. Goldman

Affiliations

Leandro José de Assis: University of Exeter, MRC Centre for Medical Mycology, Exeter, United Kingdom
Lilian Pereira Silva: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirao Preto, Brazil
Ozgur Bayram: Biology Department, Maynooth University, Maynooth, Kildare, Ireland
Paul Dowling: Biology Department, Maynooth University, Maynooth, Kildare, Ireland
Olaf Kniemeyer: ORCiD; Leibniz Institute for Natural Product Research and Infection Biology, Department of Molecular and Applied Microbiology, Institute of Microbiology, Friedrich Schiller University, Jena, Germany
Thomas Krüger: Leibniz Institute for Natural Product Research and Infection Biology, Department of Molecular and Applied Microbiology, Institute of Microbiology, Friedrich Schiller University, Jena, Germany
Axel A. Brakhage: ORCiD; Leibniz Institute for Natural Product Research and Infection Biology, Department of Molecular and Applied Microbiology, Institute of Microbiology, Friedrich Schiller University, Jena, Germany
Yingying Chen: Faculty of Health Science, University of Macau, Macau, China
Liguo Dong: Faculty of Health Science, University of Macau, Macau, China
Kaeling Tan: Faculty of Health Science, University of Macau, Macau, China
Koon Ho Wong: Faculty of Health Science, University of Macau, Macau, China
Laure N. A. Ries: University of Exeter, MRC Centre for Medical Mycology, Exeter, United Kingdom
Gustavo H. Goldman: ORCiD; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirao Preto, Brazil

DOI: https://doi.org/10.1128/mBio.03146-20
Journal volume & issue: Vol. 12, no. 1

Abstract

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In filamentous fungi, the transcription factor CreA controls carbohydrate metabolism through the regulation of genes encoding enzymes required for the use of alternative carbon sources. In this work, phosphorylation sites were identified on Aspergillus nidulans

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal