Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory

Suhel Tamboli; Sanjay Singh; Dimitry Topolnik; Mohamed El Amine Barkat; Risna Radhakrishnan; Alexandre Guet-McCreight; Lisa Topolnik

Cell Reports (Apr 2024)

Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory

Suhel Tamboli,
Sanjay Singh,
Dimitry Topolnik,
Mohamed El Amine Barkat,
Risna Radhakrishnan,
Alexandre Guet-McCreight,
Lisa Topolnik

Affiliations

Suhel Tamboli: Neuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, Canada
Sanjay Singh: Neuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, Canada
Dimitry Topolnik: Neuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, Canada
Mohamed El Amine Barkat: Neuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, Canada
Risna Radhakrishnan: Neuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, Canada
Alexandre Guet-McCreight: Krembil Centre for Neuroinformatic, University of Toronto, Toronto, ON, Canada
Lisa Topolnik: Neuroscience Axis, CRCHUQ-CHUL, Quebec City, PQ, Canada; Department of Biochemistry, Microbiology, and Bioinformatics, Université Laval, Quebec City, PQ, Canada; Corresponding author

Journal volume & issue: Vol. 43, no. 4
p. 114115

Abstract

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Summary: In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, the specific behavioral conditions that lead to circuit disinhibition remain uncertain. To investigate the behavioral relevance of VIP-IN activity, we employed wireless technologies allowing us to monitor and manipulate their function in freely behaving mice. Our findings reveal that, during spatial exploration in new environments, VIP-INs in the CA1 hippocampal region become highly active, facilitating the rapid encoding of novel spatial information. Remarkably, both VIP-INs and pyramidal neurons (PNs) exhibit increased activity when encountering novel changes in the environment, including context- and object-related alterations. Concurrently, somatostatin- and parvalbumin-expressing inhibitory populations show an inverse relationship with VIP-IN and PN activity, revealing circuit disinhibition that occurs on a timescale of seconds. Thus, VIP-IN-mediated disinhibition may constitute a crucial element in the rapid encoding of novelty and the acquisition of recognition memory.

CP: Neuroscience

Published in Cell Reports

ISSN: 2211-1247 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: http://www.cell.com/cell-reports/home

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