Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis

Suvi Häkkinen; Stephanie A. Chu; Suzee E. Lee

Neurobiology of Disease (Nov 2020)

Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis

Suvi Häkkinen,
Stephanie A. Chu,
Suzee E. Lee

Affiliations

Suvi Häkkinen: Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
Stephanie A. Chu: Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
Suzee E. Lee: Corresponding author at: UCSF Memory and Aging Center, MC: 1207, 675 Nelson Rising Lane, San Francisco, CA 94109, USA.; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA

Journal volume & issue: Vol. 145
p. 105063

Abstract

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Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have a strong clinical, genetic and pathological overlap. This review focuses on the current understanding of structural, functional and molecular neuroimaging signatures of genetic FTD and ALS. We overview quantitative neuroimaging studies on the most common genes associated with FTD (MAPT, GRN), ALS (SOD1), and both (C9orf72), and summarize visual observations of images reported in the rarer genes (CHMP2B, TARDBP, FUS, OPTN, VCP, UBQLN2, SQSTM1, TREM2, CHCHD10, TBK1).

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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Abstract

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