Nature Communications (Sep 2022)
Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency
- Woranop Sukparangsi,
- Elena Morganti,
- Molly Lowndes,
- Hélène Mayeur,
- Melanie Weisser,
- Fella Hammachi,
- Hanna Peradziryi,
- Fabian Roske,
- Jurriaan Hölzenspies,
- Alessandra Livigni,
- Benoit Gilbert Godard,
- Fumiaki Sugahara,
- Shigeru Kuratani,
- Guillermo Montoya,
- Stephen R. Frankenberg,
- Sylvie Mazan,
- Joshua M. Brickman
Affiliations
- Woranop Sukparangsi
- Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Copenhagen
- Elena Morganti
- Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Copenhagen
- Molly Lowndes
- Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Copenhagen
- Hélène Mayeur
- CNRS, Sorbonne Université, Biologie Intégrative des Organismes Marins, UMR7232
- Melanie Weisser
- Structural Molecular Biology Group, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
- Fella Hammachi
- MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, 5 Little France Drive, University of Edinburgh
- Hanna Peradziryi
- Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Copenhagen
- Fabian Roske
- Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Copenhagen
- Jurriaan Hölzenspies
- Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Copenhagen
- Alessandra Livigni
- MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, 5 Little France Drive, University of Edinburgh
- Benoit Gilbert Godard
- CNRS, Sorbonne Université, UPMC Univ Paris 06, FR2424, Development and Evolution of Vertebrates Group, Station Biologique
- Fumiaki Sugahara
- Division of Biology, Hyogo College of Medicine
- Shigeru Kuratani
- Laboratory for Evolutionary Morphology, RIKEN Center for Biosystems Dynamics Research (BDR)
- Guillermo Montoya
- Structural Molecular Biology Group, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
- Stephen R. Frankenberg
- Department of Zoology, University of Melbourne
- Sylvie Mazan
- CNRS, Sorbonne Université, Biologie Intégrative des Organismes Marins, UMR7232
- Joshua M. Brickman
- Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Copenhagen
- DOI
- https://doi.org/10.1038/s41467-022-32481-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
By constructing an evolutionary trajectory of the cyclostome-gnathostome Pou5 gene family and comparing the structural and phenotypic protein variations, the authors uncover the origin of functional characteristics for the pluripotency factor Oct4.
