MOLEKULYaRNO-GENETIChESKIE MARKERY OSTEOPOROZA U ZhITELEY BLOKADNOGO LENINGRADA

Abstract

The aim of our study is researching influence of vitamin D and osteocalcin polymorphic gene markers in people, who lived in Blockaded Leningrad in 1941-1944 and detecting “critical age” of peak bone mass formation in these people. We included in our study 48 peoples, 13 males and 35 females. Osteodensitometry of lumbar spine (L1-L4) and proximal hip was used by dualenergy X-ray absorptiometer GE Lunar Prodigy Vision 6. Molecular diagnostic researching are: detecting ApaI, TagI vitamin D receptor (VDR) and HindIII osteocalcin gene polymorphism by polymerase chain reaction with restriction assay. Women with osteopenia of hip neck had significantly higher age in the onset of Blockade, than women without osteopenia. Genotype ТТ and allele Т of TagI, aa genotype of ApaI VDR, genotype hh and allele h of HindIII osteocalcin gene polymorphism will be able as markers of genetic predisposing to osteoporosis in people, who lived in Blockaded Leningrad.

Keywords

• остеопения
• остеопороз
• рецептор витамина D
• полиморфизм гена
• остеокальцин
• генетическая предрасположенность