SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS

Abstract

Abstract. Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is established, that DNA has modulatory effect on secretion of all investigated cytokines - IL-3, GM-CSF, TNFα, INFγ and IL-10 by blood cells of healthy donors, increases their initially low concentration, reduces initially high and does not have essential influence at an average level of their secretion. Under action of DNA IFNγ level (stimulation index=3,3) increases more significantly than IL-10 level (stimulation index =1,9). Thus, salmon soft roe DNA possesses immunomodulatory properties.

Keywords

• salmon soft roe dna
• cytokines
• healthy donors
• lymphocytes
• lymphocytes subpopulations