Molecular Genetics & Genomic Medicine (Aug 2019)

Haplotype analysis of SERPINE1 gene: Risk for aneurysmal subarachnoid hemorrhage and clinical outcomes

  • Mingkuan Lin,
  • Christoph J. Griessenauer,
  • Robert M. Starke,
  • R. Shane Tubbs,
  • Mohammadali M. Shoja,
  • Paul M. Foreman,
  • Nilesh A. Vyas,
  • Beverly C. Walters,
  • Mark R. Harrigan,
  • Philipp Hendrix,
  • Winfield S. Fisher,
  • Jean‐Francois Pittet,
  • Mali Mathru,
  • Robert H. Lipsky

DOI
https://doi.org/10.1002/mgg3.737
Journal volume & issue
Vol. 7, no. 8
pp. n/a – n/a

Abstract

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Abstract Background Aneurysmal subarachnoid hemorrhage (aSAH) has high fatality and permanent disability rates due to the severe damage to brain cells and inflammation. The SERPINE1 gene that encodes PAI‐1 for the regulation of tissue plasminogen activator is considered an important therapeutic target for aSAH. Methods Six SNPs in the SERPINE1 gene (in order of rs2227631, rs1799889, rs6092, rs6090, rs2227684, rs7242) were investigated. Blood samples were genotyped with Taqman genotyping assays and pyrosequencing. The experiment‐wide statistically significant threshold for single marker analysis was set at p 140/90) (p < 0.01). Conclusion The results suggested an important regulatory role of the SERPINE1 gene polymorphism in clinical outcomes of aSAH.

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