Molecular Basis of Broad Spectrum N‑Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2

• Erik H. Klontz,
• Beatriz Trastoy,
• Daniel Deredge,
• James K. Fields,
• Chao Li,
• Jared Orwenyo,
• Alberto Marina,
• Robert Beadenkopf,
• Sebastian Günther,
• Jair Flores,
• Patrick L. Wintrode,
• Lai-Xi Wang,
• Marcelo E. Guerin,
• Eric J. Sundberg

Affiliations

Erik H. Klontz

†Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States

Beatriz Trastoy

Structural Biology Unit, CIC bioGUNE, Derio, Spain

Daniel Deredge

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, United States

James K. Fields

†Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States

Chao Li

Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, United States

Jared Orwenyo

Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, United States

Alberto Marina

Structural Biology Unit, CIC bioGUNE, Derio, Spain

Robert Beadenkopf

†Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States

Sebastian Günther

†Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States

Jair Flores

†Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States

Patrick L. Wintrode

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, United States

Lai-Xi Wang

Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, United States

Marcelo E. Guerin

Structural Biology Unit, CIC bioGUNE, Derio, Spain

Eric J. Sundberg

†Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States