Nature Communications (Mar 2018)

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

  • Jason X. Cheng,
  • Li Chen,
  • Yuan Li,
  • Adam Cloe,
  • Ming Yue,
  • Jiangbo Wei,
  • Kenneth A. Watanabe,
  • Jamile M. Shammo,
  • John Anastasi,
  • Qingxi J. Shen,
  • Richard A. Larson,
  • Chuan He,
  • Michelle M. Le Beau,
  • James W. Vardiman

DOI
https://doi.org/10.1038/s41467-018-03513-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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Resistance to chemotherapy is a serious issue that can be influenced by RNA epigenetics and chromatin structure. Here, the authors show in leukaemia cells that RNA 5-methylcytosine (RNA:m5C) and RNA:m5C methyltransferases (RCMTs) mediate chromatin structures that can modulate 5-Azacitidine response and resistance.