Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial

Anina F. van de Koolwijk; Thijs S.R. Delnoij; Martje M. Suverein; Brigitte A.B. Essers; Renicus C. Hermanides; Luuk C. Otterspoor; Carlos V. Elzo Kraemer; Alexander P.J. Vlaar; Joris J. van der Heijden; Erik Scholten; Corstiaan A. den Uil; Dinis Dos Reis Miranda; Sakir Akin; Jesse de Metz; Iwan C.C. van der Horst; Bjorn Winkens; Jos G. Maessen; Roberto Lorusso; Marcel C.G. van de Poll

Resuscitation Plus (Sep 2024)

Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial

Anina F. van de Koolwijk,
Thijs S.R. Delnoij,
Martje M. Suverein,
Brigitte A.B. Essers,
Renicus C. Hermanides,
Luuk C. Otterspoor,
Carlos V. Elzo Kraemer,
Alexander P.J. Vlaar,
Joris J. van der Heijden,
Erik Scholten,
Corstiaan A. den Uil,
Dinis Dos Reis Miranda,
Sakir Akin,
Jesse de Metz,
Iwan C.C. van der Horst,
Bjorn Winkens,
Jos G. Maessen,
Roberto Lorusso,
Marcel C.G. van de Poll

Affiliations

Anina F. van de Koolwijk: Department of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands; Corresponding author at: Department of Intensive Care Medicine, Maastricht University Medical Center+, P.O. Box 5800, 6202AZ Maastricht, The Netherlands.
Thijs S.R. Delnoij: Department of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands; Department of Cardiology, Maastricht University Medical Centre+, Maastricht University, Maastricht, The Netherlands
Martje M. Suverein: Department of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands
Brigitte A.B. Essers: Department of Clinical Epidemiology and Medical Technical Assessment, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands
Renicus C. Hermanides: Department of Cardiology, Isala Clinics, Zwolle, The Netherlands
Luuk C. Otterspoor: Department of Intensive Care, Catharina Hospital, Eindhoven, The Netherlands
Carlos V. Elzo Kraemer: Department of Intensive Care, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
Alexander P.J. Vlaar: Department of Intensive Care, Amsterdam University Medical Center Location AMC, University, Amsterdam, Amsterdam, The Netherlands
Joris J. van der Heijden: Department of Intensive Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
Erik Scholten: Department of Intensive Care, St. Antonius Hospital, Nieuwegein, The Netherlands
Corstiaan A. den Uil: Department of Intensive Care, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands; Department of Cardiology, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands; Department of Intensive Care, Maasstad Hospital, Rotterdam, The Netherlands
Dinis Dos Reis Miranda: Department of Intensive Care, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands
Sakir Akin: Department of Intensive Care, Haga Hospital, The Hague, The Netherlands
Jesse de Metz: Department of Intensive Care, OLVG, Amsterdam, The Netherlands
Iwan C.C. van der Horst: Department of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands
Bjorn Winkens: Department of Methodology & Statistics, Maastricht University, Maastricht, The Netherlands; Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands
Jos G. Maessen: Department of Cardiothoracic Surgery, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands
Roberto Lorusso: Department of Cardiothoracic Surgery, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands
Marcel C.G. van de Poll: Department of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands; School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands

Journal volume & issue: Vol. 19
p. 100669

Abstract

Read online

Background: Prospective, trial-based data comparing health-related quality of life (HRQoL) in patients surviving out-of-hospital cardiac arrest (OHCA) through extracorporeal cardiopulmonary resuscitation (ECPR) or conventional CPR (CCPR) are scarce. We aimed to determine HRQoL during 1-year after refractory OHCA in patients treated with ECPR and CCPR. Methods: We present a secondary analysis of the multicenter INCEPTION-trial, which studied the effectiveness of ECPR versus CCPR in patients with refractory OHCA. HRQoL was prospectively assessed using the EQ-5D-5L questionnaire. Poor HRQoL was pragmatically defined as an EQ-5D-5L health utility index (HUI) > 1 SD below the age-adjusted norm. We used mixed linear models to assess the difference in HRQoL over time and univariable analyses to assess factors potentially associated with poor HRQoL. Results: A total of 134 patients were enrolled, and hospital survival was 20% (27 patients). EQ-5D-5L data were available for 25 patients (5 ECPR and 20 CCPR). One year after OHCA, the estimated mean HUI was 0.73 (0.05) in all patients, 0.84 (0.12) in ECPR survivors, and 0.71 (0.05) in CCPR survivors (p-value 0.31). Eight (32%) survivors had a poor HRQoL. HRQoL was good in 17 (68%) patients, with 100% in ECPR survivors versus 60% in CCPR survivors (p-value 0.14). Conclusion: One year after refractory OHCA, 68% of the survivors had a good HRQoL. We found no statistically significant difference in HRQoL one year after OHCA in patients treated with ECPR compared to CCPR. However, numerical differences may be clinically relevant in favor of ECPR.

Published in Resuscitation Plus

ISSN: 2666-5204 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine
Website: https://www.journals.elsevier.com/resuscitation-plus

About the journal

Abstract

Keywords