Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report

Kohei Okada; Rie Sakakibara; Takayuki Honda; Takahiro Mitsumura; Sho Shibata; Tsuyoshi Shirai; Tsukasa Okamoto; Haruhiko Furusawa; Tomoya Tateishi; Yasunari Miyazaki

Respiratory Medicine Case Reports (Jan 2023)

Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report

Kohei Okada,
Rie Sakakibara,
Takayuki Honda,
Takahiro Mitsumura,
Sho Shibata,
Tsuyoshi Shirai,
Tsukasa Okamoto,
Haruhiko Furusawa,
Tomoya Tateishi,
Yasunari Miyazaki

Affiliations

Kohei Okada: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Rie Sakakibara: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan; Corresponding author.
Takayuki Honda: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Takahiro Mitsumura: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan; Department of Pulmonary Immunotherapeutic, Tokyo Medical and Dental University, Tokyo, Japan
Sho Shibata: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Tsuyoshi Shirai: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Tsukasa Okamoto: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan; Department of Pulmonary Immunotherapeutic, Tokyo Medical and Dental University, Tokyo, Japan
Haruhiko Furusawa: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Tomoya Tateishi: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Yasunari Miyazaki: Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Journal volume & issue: Vol. 46
p. 101929

Abstract

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A 74-year-old man was referred to our hospital with an abnormal chest shadow. Computed tomography (CT) revealed a mass in the left upper lobe and interstitial pneumonia (IP). The patient underwent CT-guided needle biopsy and was diagnosed as lung adenocarcinoma with cT2aN1M1a Stage IVA (PUL). The patient was administered 6 cycles of CBDCA + nab-paclitaxel as first-line, 3 cycles of atezolizumab as second-line, and 8 cycles of S-1 as third-line treatment but finally showed tumor progression. Because comprehensive genome profiling test revealed KRAS G12C mutation, sotorasib was initiated as fourth-line treatment and showed tumor regression without exacerbation of pre-existing IP.

Published in Respiratory Medicine Case Reports

ISSN: 2213-0071 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: http://www.journals.elsevier.com/respiratory-medicine-case-reports/

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