Biological synthesis of zinc oxide nanoparticles from the plant extract, Wattakaka volubilis showed anti-microbial and anti-hyperglycemic effects

Abstract

Background: In this study, a synthesis of zinc oxide nanoparticles (ZnONPs) was performed using Wattakaka volubilis leaf extract as a reducing and capping agent. The plant leaf extract contains various secondary metabolites, other nutritional and medicinal products. Methods: The prepared ZnONPs were characterized using Ultra Violet-visible Spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) coupled with Energy Dispersive X-ray spectroscopy (EDX). The anti-bacterial study was done by the well diffusion method. Results: The synthesized ZnONPs were spherical in shape, ranging from 100 to 200 nm. The FTIR bands were sharp with strong absorption peaks at 414.70 cm−1, showing the Zn group's presence. The zinc oxide nanoparticles anti-bacterial effects were tested in gram-positive Staphyllococcus epidermidis (MTTC 9040) and gram-negative Enterobacter aeurogens (MTCC 8100). ZnONPs showed excellent anti hyperglycemic potential in zebrafish adults in the present work. Conclusion: The zinc oxide nanoparticles have been effectively developed for antimicrobial in diabetic-based wound healing applications in biomedical fields. The findings of the current study have provided several interesting new avenues for future research exploration.

Keywords

• Wattakaka volubilis
• ZnONPs
• Staphyllococcus epidermidis
• Enterobacter aeurogens
• Antimicrobial
• Alloxan and antihyperglycemic