Role of vitamin D and some immunological markers in polycystic ovarian syndrome.

Abstract

Polycystic ovarian syndrome (PCOS) is the most widespread endocrine-metabolic disorder in women of reproductive age, which is a very common disorder. The current study aimed to determine the levels of vitamin D and immunological markers like antinuclear antibodies (ANA), anti-double strand DNA (dsDNA) and C. reactive protein (CRP) in the serum of PCOS-affected women. Blood samples were collected from forty polycystic women depending on the Rotterdam criteria. Forty fertile women of similar ages made up the control group. The Blood samples were analyzed to measure the levels of an endocrine hormone and vitamin D by Cobas e411; ANA and ds DNA determined by Enzyme-Linked Immunosorbent Assay ( ELISA), And CRP measured by Cobas C111. This study revealed a significant decrease in vitamin D in PCOS patients contrasted to the control group, while CRP, ANA, and dsDNA increased significantly in PCOS patients. Finding low vitamin D and high ANA, ds DNA in PCOS women may have a role in the aetiology of PCOS. Screening for autoantibodies and vitamin D in women with PCOS may provide better insight into its role in PCOS.

Keywords

• Autoimmune markers
• C. reactive protein
• Polycystic ovary syndrome
• Vitamin D