Nature Communications (Feb 2017)
Arylmethylamino steroids as antiparasitic agents
- Reimar Krieg,
- Esther Jortzik,
- Alice-Anne Goetz,
- Stéphanie Blandin,
- Sergio Wittlin,
- Mourad Elhabiri,
- Mahsa Rahbari,
- Selbi Nuryyeva,
- Kerstin Voigt,
- Hans-Martin Dahse,
- Axel Brakhage,
- Svenja Beckmann,
- Thomas Quack,
- Christoph G. Grevelding,
- Anthony B. Pinkerton,
- Bruno Schönecker,
- Jeremy Burrows,
- Elisabeth Davioud-Charvet,
- Stefan Rahlfs,
- Katja Becker
Affiliations
- Reimar Krieg
- Institute of Anatomy II, University Hospital Jena, Teichgraben 7
- Esther Jortzik
- Biochemistry and Molecular Biology, Interdisciplinary Research Centre, Justus Liebig University Giessen
- Alice-Anne Goetz
- Université de Strasbourg, CNRS, Inserm, MIR UPR9022/U963
- Stéphanie Blandin
- Université de Strasbourg, CNRS, Inserm, MIR UPR9022/U963
- Sergio Wittlin
- Swiss Tropical and Public Health Institute
- Mourad Elhabiri
- UMR 7509 Centre National de la Recherche Scientifique and University of Strasbourg, European School of Chemistry, Polymers and Materials (ECPM)
- Mahsa Rahbari
- Biochemistry and Molecular Biology, Interdisciplinary Research Centre, Justus Liebig University Giessen
- Selbi Nuryyeva
- UMR 7509 Centre National de la Recherche Scientifique and University of Strasbourg, European School of Chemistry, Polymers and Materials (ECPM)
- Kerstin Voigt
- Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI)
- Hans-Martin Dahse
- Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI)
- Axel Brakhage
- Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI)
- Svenja Beckmann
- Institute of Parasitology, Biomedical Research Centre, Justus Liebig University Giessen
- Thomas Quack
- Institute of Parasitology, Biomedical Research Centre, Justus Liebig University Giessen
- Christoph G. Grevelding
- Institute of Parasitology, Biomedical Research Centre, Justus Liebig University Giessen
- Anthony B. Pinkerton
- Conrad Prebys Center for Chemical Genomics, Sanford-Burnham-Prebys Medical Discovery Institute
- Bruno Schönecker
- Institute of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena
- Jeremy Burrows
- Medicines for Malaria Venture, 20 Route de Pré-Bois
- Elisabeth Davioud-Charvet
- UMR 7509 Centre National de la Recherche Scientifique and University of Strasbourg, European School of Chemistry, Polymers and Materials (ECPM)
- Stefan Rahlfs
- Biochemistry and Molecular Biology, Interdisciplinary Research Centre, Justus Liebig University Giessen
- Katja Becker
- Biochemistry and Molecular Biology, Interdisciplinary Research Centre, Justus Liebig University Giessen
- DOI
- https://doi.org/10.1038/ncomms14478
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Steroid units can facilitate membrane permeation and bioavailability in drugs. Here, using a medicinal chemistry program, Krieget al. identify an arylmethylamino steroid that kills Plasmodium parasites, likely through a chelate-based quinone methide mechanism, and has activity against Schistosoma mansoni.
