A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Huina Guo; Huina Guo; YiChen Lou; YiChen Lou; YiChen Lou; Xiaofang Hou; Xiaofang Hou; Xiaofang Hou; Qi Han; Qi Han; Yujia Guo; Yujia Guo; Zhongxun Li; Zhongxun Li; Xiaoya Guan; Xiaoya Guan; Hongliang Liu; Hongliang Liu; Hongliang Liu; Hongliang Liu; Chunming Zhang; Chunming Zhang; Chunming Zhang

doi:10.3389/fphar.2024.1415147

Frontiers in Pharmacology (May 2024)

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Huina Guo,
Huina Guo,
YiChen Lou,
YiChen Lou,
YiChen Lou,
Xiaofang Hou,
Xiaofang Hou,
Xiaofang Hou,
Qi Han,
Qi Han,
Yujia Guo,
Yujia Guo,
Zhongxun Li,
Zhongxun Li,
Xiaoya Guan,
Xiaoya Guan,
Hongliang Liu,
Hongliang Liu,
Hongliang Liu,
Hongliang Liu,
Chunming Zhang,
Chunming Zhang,
Chunming Zhang

Affiliations

Huina Guo: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Huina Guo: Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
YiChen Lou: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
YiChen Lou: Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
YiChen Lou: The First Clinical Medical College of Shanxi Medical University, Taiyuan, China
Xiaofang Hou: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Xiaofang Hou: Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Xiaofang Hou: The First Clinical Medical College of Shanxi Medical University, Taiyuan, China
Qi Han: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Qi Han: Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Yujia Guo: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Yujia Guo: Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Zhongxun Li: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Zhongxun Li: Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Xiaoya Guan: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Xiaoya Guan: Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Hongliang Liu: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Hongliang Liu: Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Hongliang Liu: Department of Otolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, China
Hongliang Liu: Department of Cell Biology and Genetics, The Basic Medical School of Shanxi Medical University, Taiyuan, Shanxi, China
Chunming Zhang: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Chunming Zhang: Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Chunming Zhang: Department of Otolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, China

DOI: https://doi.org/10.3389/fphar.2024.1415147
Journal volume & issue: Vol. 15

Abstract

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As a traditional Chinese medicinal herb with a long history, Codonopsis pilosula (CP) has attracted much attention from the medical community in recent years. This review summarizes the research progress of CP in the medical field in the past 5 years. By searching and analyzing the literature, and combining with Cytoscape software, we comprehensively examined the role and mechanism of action of CP in individual application, combination drug application, and the role and mechanism of action of codonopsis pilosula’s active ingredients in a variety of diseases. It also analyzes the medicinal use of CP and its application value in medicine. This review found that CP mainly manifests important roles in several diseases, such as cardiovascular system, nervous system, digestive system, immune system, etc., and regulates the development of many diseases mainly through the mechanisms of inflammation regulation, oxidative stress, immunomodulation and apoptosis. Its rich pharmacological activities and diverse medicinal effects endow CP with broad prospects and application values. This review provides valuable reference and guidance for the further development of CP in traditional Chinese medicine.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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