Nature Communications (Aug 2016)
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
- Patrizia Cammareri,
- Aidan M. Rose,
- David F. Vincent,
- Jun Wang,
- Ai Nagano,
- Silvana Libertini,
- Rachel A. Ridgway,
- Dimitris Athineos,
- Philip J. Coates,
- Angela McHugh,
- Celine Pourreyron,
- Jasbani H. S. Dayal,
- Jonas Larsson,
- Simone Weidlich,
- Lindsay C. Spender,
- Gopal P. Sapkota,
- Karin J. Purdie,
- Charlotte M. Proby,
- Catherine A. Harwood,
- Irene M. Leigh,
- Hans Clevers,
- Nick Barker,
- Stefan Karlsson,
- Catrin Pritchard,
- Richard Marais,
- Claude Chelala,
- Andrew P. South,
- Owen J. Sansom,
- Gareth J. Inman
Affiliations
- Patrizia Cammareri
- Wnt Signaling and Colorectal Cancer Group, Cancer Research UK Beatson Institute, Institute of Cancer Sciences, Glasgow University
- Aidan M. Rose
- Division of Cancer Research, School of Medicine, University of Dundee
- David F. Vincent
- Wnt Signaling and Colorectal Cancer Group, Cancer Research UK Beatson Institute, Institute of Cancer Sciences, Glasgow University
- Jun Wang
- Bioinformatics Unit, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square
- Ai Nagano
- Bioinformatics Unit, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square
- Silvana Libertini
- Wnt Signaling and Colorectal Cancer Group, Cancer Research UK Beatson Institute, Institute of Cancer Sciences, Glasgow University
- Rachel A. Ridgway
- Wnt Signaling and Colorectal Cancer Group, Cancer Research UK Beatson Institute, Institute of Cancer Sciences, Glasgow University
- Dimitris Athineos
- Wnt Signaling and Colorectal Cancer Group, Cancer Research UK Beatson Institute, Institute of Cancer Sciences, Glasgow University
- Philip J. Coates
- Tayside Tissue Bank, School of Medicine, University of Dundee
- Angela McHugh
- Division of Cancer Research, School of Medicine, University of Dundee
- Celine Pourreyron
- Division of Cancer Research, School of Medicine, University of Dundee
- Jasbani H. S. Dayal
- Division of Cancer Research, School of Medicine, University of Dundee
- Jonas Larsson
- Molecular Medicine and Gene Therapy, Lund Strategic Center for Stem Cell Biology, Lund University
- Simone Weidlich
- MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee
- Lindsay C. Spender
- Division of Cancer Research, School of Medicine, University of Dundee
- Gopal P. Sapkota
- MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee
- Karin J. Purdie
- Centre for Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Charlotte M. Proby
- Division of Cancer Research, School of Medicine, University of Dundee
- Catherine A. Harwood
- Centre for Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Irene M. Leigh
- Division of Cancer Research, School of Medicine, University of Dundee
- Hans Clevers
- Hubrecht Institute
- Nick Barker
- Institute of Medical Biology
- Stefan Karlsson
- Molecular Medicine and Gene Therapy, Lund Strategic Center for Stem Cell Biology, Lund University
- Catrin Pritchard
- Department of Biochemistry, University of Leicester
- Richard Marais
- The Paterson Institute for Cancer Research
- Claude Chelala
- Bioinformatics Unit, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square
- Andrew P. South
- Division of Cancer Research, School of Medicine, University of Dundee
- Owen J. Sansom
- Wnt Signaling and Colorectal Cancer Group, Cancer Research UK Beatson Institute, Institute of Cancer Sciences, Glasgow University
- Gareth J. Inman
- Division of Cancer Research, School of Medicine, University of Dundee
- DOI
- https://doi.org/10.1038/ncomms12493
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous squamous cell carcinomas.
