NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

Aled J. Parry; Matthew Hoare; Dóra Bihary; Robert Hänsel-Hertsch; Stephen Smith; Kosuke Tomimatsu; Elizabeth Mannion; Amy Smith; Paula D’Santos; I. Alasdair Russell; Shankar Balasubramanian; Hiroshi Kimura; Shamith A. Samarajiwa; Masashi Narita

doi:10.1038/s41467-018-04283-9

Nature Communications (May 2018)

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

Aled J. Parry,
Matthew Hoare,
Dóra Bihary,
Robert Hänsel-Hertsch,
Stephen Smith,
Kosuke Tomimatsu,
Elizabeth Mannion,
Amy Smith,
Paula D’Santos,
I. Alasdair Russell,
Shankar Balasubramanian,
Hiroshi Kimura,
Shamith A. Samarajiwa,
Masashi Narita

Affiliations

Aled J. Parry: Cancer Research UK Cambridge Institute, University of Cambridge
Matthew Hoare: Cancer Research UK Cambridge Institute, University of Cambridge
Dóra Bihary: MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge
Robert Hänsel-Hertsch: Cancer Research UK Cambridge Institute, University of Cambridge
Stephen Smith: Department of Pathology, Addenbrooke’s Hospital, University of Cambridge
Kosuke Tomimatsu: Cancer Research UK Cambridge Institute, University of Cambridge
Elizabeth Mannion: Cancer Research UK Cambridge Institute, University of Cambridge
Amy Smith: Cancer Research UK Cambridge Institute, University of Cambridge
Paula D’Santos: Cancer Research UK Cambridge Institute, University of Cambridge
I. Alasdair Russell: Cancer Research UK Cambridge Institute, University of Cambridge
Shankar Balasubramanian: Cancer Research UK Cambridge Institute, University of Cambridge
Hiroshi Kimura: Cell Biology Centre, Institute of Innovative Research, Tokyo Institute of Technology
Shamith A. Samarajiwa: MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge
Masashi Narita: Cancer Research UK Cambridge Institute, University of Cambridge

DOI: https://doi.org/10.1038/s41467-018-04283-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Notch can drive senescence in a cell contact dependent manner. Here the authors show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously via the JAG1-NOTCH-HMGA1 interplay during senescence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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