Frontiers in Neuroscience (Oct 2022)
Explore the effects of overweight and smoking on spontaneous brain activity: Independent and reverse
- Xinyu Gao,
- Xinyu Gao,
- Xinyu Gao,
- Xinyu Gao,
- Xinyu Gao,
- Xinyu Gao,
- Xinyu Gao,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Mengzhe Zhang,
- Zhengui Yang,
- Zhengui Yang,
- Zhengui Yang,
- Zhengui Yang,
- Zhengui Yang,
- Zhengui Yang,
- Zhengui Yang,
- Xiaoyu Niu,
- Xiaoyu Niu,
- Xiaoyu Niu,
- Xiaoyu Niu,
- Xiaoyu Niu,
- Xiaoyu Niu,
- Xiaoyu Niu,
- Jingli Chen,
- Jingli Chen,
- Jingli Chen,
- Jingli Chen,
- Jingli Chen,
- Jingli Chen,
- Jingli Chen,
- Bingqian Zhou,
- Bingqian Zhou,
- Bingqian Zhou,
- Bingqian Zhou,
- Bingqian Zhou,
- Bingqian Zhou,
- Bingqian Zhou,
- Weijian Wang,
- Weijian Wang,
- Weijian Wang,
- Weijian Wang,
- Weijian Wang,
- Weijian Wang,
- Weijian Wang,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang
Affiliations
- Xinyu Gao
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xinyu Gao
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Xinyu Gao
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Xinyu Gao
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Xinyu Gao
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Xinyu Gao
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Xinyu Gao
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Mengzhe Zhang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Mengzhe Zhang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Mengzhe Zhang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Mengzhe Zhang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Mengzhe Zhang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Mengzhe Zhang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Mengzhe Zhang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Zhengui Yang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Zhengui Yang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Zhengui Yang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Zhengui Yang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Zhengui Yang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Zhengui Yang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Zhengui Yang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Xiaoyu Niu
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xiaoyu Niu
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Xiaoyu Niu
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Xiaoyu Niu
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Xiaoyu Niu
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Xiaoyu Niu
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Xiaoyu Niu
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Jingli Chen
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Jingli Chen
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Jingli Chen
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Jingli Chen
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Jingli Chen
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Jingli Chen
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Jingli Chen
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Bingqian Zhou
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Bingqian Zhou
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Bingqian Zhou
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Bingqian Zhou
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Bingqian Zhou
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Bingqian Zhou
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Bingqian Zhou
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Weijian Wang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Weijian Wang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Weijian Wang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Weijian Wang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Weijian Wang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Weijian Wang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Weijian Wang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Yarui Wei
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yarui Wei
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Yarui Wei
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Yarui Wei
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Yarui Wei
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Yarui Wei
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Yarui Wei
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Yong Zhang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yong Zhang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Yong Zhang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Yong Zhang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- DOI
- https://doi.org/10.3389/fnins.2022.944768
- Journal volume & issue
-
Vol. 16
Abstract
Accumulating evidence suggested that overweight and smoking often co-exist. However, current neuroimaging researches have almost always studied smoking or overweight status separately. Here we sought to investigate the neurobiological mechanisms of this comorbid association, by detecting spontaneous brain activity changes associated with smoking and weight status separately and collectively. We used 2 × 2 factorial design and included the following four groups: overweight/normal-weight smokers (n = 34/n = 30) and overweight/normal-weight non-smokers (n = 22/n = 24). The spontaneous brain activity among the four groups was comparable using an amplitude of low-frequency fluctuation (ALFF) method based on resting-state fMRI (rs-fMRI). Furthermore, correlation analyses between brain activity changes, smoking severity and BMI values were performed. A main effect of smoking was discovered in the default mode network (DMN) and visual network related brain regions. Moreover, overweight people had high ALFF value in the brain regions associated with reward and executive control. More importantly, smoking and overweight both affected brain activity of the middle temporal gyrus (MTG), but the effect was opposite. And the brain activity of MTG was negatively correlated with smoking years, pack year and BMI value. These results suggest that smoking and overweight not only affect spontaneous brain activity alone, but also paradoxically affect spontaneous brain activity in the MTG. This suggests that we need to control for weight as a variable when studying spontaneous brain activity in smokers. Besides, this interaction may provide a neurological explanation for the comorbidity of overweight and smoking and a target for the treatment of comorbid populations.
Keywords