Bimodal sensing of guidance cues in mechanically distinct microenvironments

Erdem D. Tabdanov; Vikram V. Puram; Zaw Win; Ashab Alamgir; Patrick W. Alford; Paolo P. Provenzano

doi:10.1038/s41467-018-07290-y

Nature Communications (Nov 2018)

Bimodal sensing of guidance cues in mechanically distinct microenvironments

Erdem D. Tabdanov,
Vikram V. Puram,
Zaw Win,
Ashab Alamgir,
Patrick W. Alford,
Paolo P. Provenzano

Affiliations

Erdem D. Tabdanov: Department of Biomedical Engineering, University of Minnesota
Vikram V. Puram: Department of Biomedical Engineering, University of Minnesota
Zaw Win: Department of Biomedical Engineering, University of Minnesota
Ashab Alamgir: Department of Biomedical Engineering, University of Minnesota
Patrick W. Alford: Department of Biomedical Engineering, University of Minnesota
Paolo P. Provenzano: Department of Biomedical Engineering, University of Minnesota

DOI: https://doi.org/10.1038/s41467-018-07290-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 18

Abstract

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Invasive cells respond to contact guidance cues during migration. Here, using micro- and nanopatterning with different ligands and varying stiffness, the authors find that cells can make cellular protrusions through both contractility-dependent and contractility-independent means.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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