Pten is necessary for the quiescence and maintenance of adult muscle stem cells

Feng Yue; Pengpeng Bi; Chao Wang; Tizhong Shan; Yaohui Nie; Timothy L. Ratliff; Timothy P. Gavin; Shihuan Kuang

doi:10.1038/ncomms14328

Nature Communications (Jan 2017)

Pten is necessary for the quiescence and maintenance of adult muscle stem cells

Feng Yue,
Pengpeng Bi,
Chao Wang,
Tizhong Shan,
Yaohui Nie,
Timothy L. Ratliff,
Timothy P. Gavin,
Shihuan Kuang

Affiliations

Feng Yue: Department of Animal Sciences, Purdue University, 901 W State Street
Pengpeng Bi: Department of Animal Sciences, Purdue University, 901 W State Street
Chao Wang: Department of Animal Sciences, Purdue University, 901 W State Street
Tizhong Shan: Department of Animal Sciences, Purdue University, 901 W State Street
Yaohui Nie: Department of Animal Sciences, Purdue University, 901 W State Street
Timothy L. Ratliff: Center for Cancer Research, Purdue University
Timothy P. Gavin: Department of Health and Kinesiology, Purdue University
Shihuan Kuang: Department of Animal Sciences, Purdue University, 901 W State Street

DOI: https://doi.org/10.1038/ncomms14328
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Pten is known to regulate haematopoietic stem cell functions. Here the authors show that Ptenalteration of Notch signalling has stage-specific muscle regenerative functions in muscle stem cells by preventing premature differentiation of quiescent cells and enhancing the self-renewal of activated cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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