Journal of Experimental & Clinical Cancer Research (Dec 2022)
RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer
- Huijie Yang,
- Min Xue,
- Peng Su,
- Yan Zhou,
- Xin Li,
- Zhongbo Li,
- Yan Xia,
- Chenmiao Zhang,
- Mingxi Fu,
- Xiuxia Zheng,
- Guosheng Luo,
- Tian Wei,
- Xinxing Wang,
- Yinlu Ding,
- Jian Zhu,
- Ting Zhuang
Affiliations
- Huijie Yang
- Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Laboratory Medicine, Xinxiang Medical University
- Min Xue
- Molecular Biology Laboratory, First People’s Hospital of Shangqiu
- Peng Su
- Department of Pathology, Shandong University Qilu Hospital, Cheeloo College of Medicine, Shandong University
- Yan Zhou
- Department of General Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University
- Xin Li
- Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Laboratory Medicine, Xinxiang Medical University
- Zhongbo Li
- Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Laboratory Medicine, Xinxiang Medical University
- Yan Xia
- Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Laboratory Medicine, Xinxiang Medical University
- Chenmiao Zhang
- Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Laboratory Medicine, Xinxiang Medical University
- Mingxi Fu
- Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Laboratory Medicine, Xinxiang Medical University
- Xiuxia Zheng
- Molecular Biology Laboratory, First People’s Hospital of Shangqiu
- Guosheng Luo
- The Affiliated people’s Hospital of Xinxiang Medical University
- Tian Wei
- Department of General Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University
- Xinxing Wang
- Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University
- Yinlu Ding
- Department of General Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University
- Jian Zhu
- Department of General Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University
- Ting Zhuang
- Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Laboratory Medicine, Xinxiang Medical University
- DOI
- https://doi.org/10.1186/s13046-022-02576-y
- Journal volume & issue
-
Vol. 41,
no. 1
pp. 1 – 18
Abstract
Highlights 1. RNF31 restrains cancer cell progression in TNBC. 2. RNF31 regulates YAP protein stability via promoting YAP K48-linked poly-ubiquitination. 3. RNF31 represses immune evasion via suppressing YAP/PD-L1 axis in TNBC.
Keywords
