Nature Communications (Sep 2020)
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma
- Stephen T. Magill,
- Harish N. Vasudevan,
- Kyounghee Seo,
- Javier E. Villanueva-Meyer,
- Abrar Choudhury,
- S. John Liu,
- Melike Pekmezci,
- Sarah Findakly,
- Stephanie Hilz,
- Sydney Lastella,
- Benjamin Demaree,
- Steve E. Braunstein,
- Nancy Ann Oberheim Bush,
- Manish K. Aghi,
- Philip V. Theodosopoulos,
- Penny K. Sneed,
- Adam R. Abate,
- Mitchel S. Berger,
- Michael W. McDermott,
- Daniel A. Lim,
- Erik M. Ullian,
- Joseph F. Costello,
- David R. Raleigh
Affiliations
- Stephen T. Magill
- Department of Neurological Surgery, University of California San Francisco
- Harish N. Vasudevan
- Department of Neurological Surgery, University of California San Francisco
- Kyounghee Seo
- Department of Neurological Surgery, University of California San Francisco
- Javier E. Villanueva-Meyer
- Department of Radiology and Biomedical Imaging, University of California San Francisco
- Abrar Choudhury
- Department of Neurological Surgery, University of California San Francisco
- S. John Liu
- Department of Neurological Surgery, University of California San Francisco
- Melike Pekmezci
- Department of Pathology, University of California San Francisco
- Sarah Findakly
- Department of Neurological Surgery, University of California San Francisco
- Stephanie Hilz
- Department of Neurological Surgery, University of California San Francisco
- Sydney Lastella
- Department of Neurological Surgery, University of California San Francisco
- Benjamin Demaree
- Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California San Francisco
- Steve E. Braunstein
- Department of Radiation Oncology, University of California San Francisco
- Nancy Ann Oberheim Bush
- Department of Neurological Surgery, University of California San Francisco
- Manish K. Aghi
- Department of Neurological Surgery, University of California San Francisco
- Philip V. Theodosopoulos
- Department of Neurological Surgery, University of California San Francisco
- Penny K. Sneed
- Department of Radiation Oncology, University of California San Francisco
- Adam R. Abate
- Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California San Francisco
- Mitchel S. Berger
- Department of Neurological Surgery, University of California San Francisco
- Michael W. McDermott
- Department of Neurological Surgery, University of California San Francisco
- Daniel A. Lim
- Department of Neurological Surgery, University of California San Francisco
- Erik M. Ullian
- Department of Ophthalmology, University of California San Francisco
- Joseph F. Costello
- Department of Neurological Surgery, University of California San Francisco
- David R. Raleigh
- Department of Neurological Surgery, University of California San Francisco
- DOI
- https://doi.org/10.1038/s41467-020-18582-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Meningiomas are heterogeneous tumours. Here, the authors analysed genetic, epigenetic, and transcriptomic features across spatially-distinct meningioma samples to identify molecular programs underlying tumorigenesis that can be detected preoperatively using magnetic resonance imaging.
