The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study

Theresa Paulus; Lynn Wernecke; Annik Lundie; Julia Friedrich; Julius Verrel; Tina Rawish; Anne Weissbach; Christian Frings; Christian Beste; Tobias Bäumer; Alexander Münchau

doi:10.3390/biomedicines11030980

Biomedicines (Mar 2023)

The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study

Theresa Paulus,
Lynn Wernecke,
Annik Lundie,
Julia Friedrich,
Julius Verrel,
Tina Rawish,
Anne Weissbach,
Christian Frings,
Christian Beste,
Tobias Bäumer,
Alexander Münchau

Affiliations

Theresa Paulus: Institute of Systems Motor Science, University of Lübeck, 23562 Lübeck, Germany
Lynn Wernecke: Institute of Systems Motor Science, University of Lübeck, 23562 Lübeck, Germany
Annik Lundie: Institute of Systems Motor Science, University of Lübeck, 23562 Lübeck, Germany
Julia Friedrich: Institute of Systems Motor Science, University of Lübeck, 23562 Lübeck, Germany
Julius Verrel: Institute of Systems Motor Science, University of Lübeck, 23562 Lübeck, Germany
Tina Rawish: Institute of Systems Motor Science, University of Lübeck, 23562 Lübeck, Germany
Anne Weissbach: Institute of Systems Motor Science, University of Lübeck, 23562 Lübeck, Germany
Christian Frings: Department of Cognitive Psychology, Faculty of Psychology, University of Trier, 54296 Trier, Germany
Christian Beste: Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany
Tobias Bäumer: Institute of Systems Motor Science, University of Lübeck, 23562 Lübeck, Germany
Alexander Münchau: Institute of Systems Motor Science, University of Lübeck, 23562 Lübeck, Germany

DOI: https://doi.org/10.3390/biomedicines11030980
Journal volume & issue: Vol. 11, no. 3
p. 980

Abstract

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Increased activity in the left inferior parietal cortex (BA40) plays a role in the generation of tics in the Gilles de la Tourette syndrome (GTS). Thus, inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to BA40 was hypothesized to alleviate symptoms in GTS. We investigated the immediate effects of single-session 1 Hz rTMS and sham stimulation delivered to the left BA40 on tics assessed with the Rush video protocol in 29 adults with GTS. There were no significant effects on tic symptoms following rTMS or sham stimulation. Moreover, there was no difference when comparing the effects of both stimulation conditions. Bayesian statistics indicated substantial evidence against an intervention effect. The left BA40 appears not to be a useful target for 1 Hz rTMS to modulate tic symptoms in GTS patients.

Published in Biomedicines

ISSN: 2227-9059 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/biomedicines

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