Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models

Alfonso Varela-López; José M. Romero-Márquez; María D. Navarro-Hortal; César L. Ramirez-Tortosa; Maurizio Battino; Tamara Y. Forbes-Hernández; José L. Quiles

Experimental Gerontology (Jul 2023)

Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models

Alfonso Varela-López,
José M. Romero-Márquez,
María D. Navarro-Hortal,
César L. Ramirez-Tortosa,
Maurizio Battino,
Tamara Y. Forbes-Hernández,
José L. Quiles

Affiliations

Alfonso Varela-López: Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, Avda del Conocimiento s/n, Parque Tecnologico de la Salud, Armilla, Granada 18016, Spain
José M. Romero-Márquez: Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, Avda del Conocimiento s/n, Parque Tecnologico de la Salud, Armilla, Granada 18016, Spain
María D. Navarro-Hortal: Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, Avda del Conocimiento s/n, Parque Tecnologico de la Salud, Armilla, Granada 18016, Spain
César L. Ramirez-Tortosa: UGC de Anatomía Patológica Hospital San Cecilio de Granada, Granada, Spain
Maurizio Battino: Department of Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy; International Joint Research Laboratory of Intelligent Agriculture and Agri-products Processing, Jiangsu University, Zhenjiang 212013, China
Tamara Y. Forbes-Hernández: Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, Avda del Conocimiento s/n, Parque Tecnologico de la Salud, Armilla, Granada 18016, Spain
José L. Quiles: Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, Avda del Conocimiento s/n, Parque Tecnologico de la Salud, Armilla, Granada 18016, Spain; Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres, 21, 39011 Santander, Spain; Research and Development Functional Food Centre (CIDAF), Health Science Technological Park, Avenida del Conocimiento 37, 18016 Granada, Spain; Corresponding author at: Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, Avda del Conocimiento s/n, Parque Tecnologico de la Salud, Armilla, Granada 18016, Spain.

Journal volume & issue: Vol. 178
p. 112221

Abstract

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The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of all age-associated chronic disorders can be delayed because these pathologies share age as primary underlying risk factor. One of the most extended ideas is that aging is consequence of the accumulation of molecular damage. According to the oxidative damage theory, antioxidants should slow down aging, extending lifespan and healthspan. The present review analyzes studies evaluating the effect of dietary antioxidants on lifespan of different aging models and discusses the evidence on favor of their antioxidant activity as anti-aging mechanisms. Moreover, possible causes for differences between the reported results are evaluated.

Published in Experimental Gerontology

ISSN: 1873-6815 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine; Science: Biology (General)
Website: https://www.sciencedirect.com/journal/experimental-gerontology

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