PLoS ONE (Jan 2013)

The administration of 100% oxygen and respiratory drive in very preterm infants at birth.

  • Jeroen J van Vonderen,
  • Nadia E Narayen,
  • Frans J Walther,
  • Melissa L Siew,
  • Peter G Davis,
  • Stuart B Hooper,
  • Arjan B te Pas

DOI
https://doi.org/10.1371/journal.pone.0076898
Journal volume & issue
Vol. 8, no. 10
p. e76898

Abstract

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AimTo retrospectively investigate the changes of SpO2 and respiratory drive in preterm infants at birth after administration of 100% oxygen.MethodsRespiratory parameters, FiO2 and oximetry of infants ResultsResults are given as median (IQR) or percentages where appropriate. Suitable recordings were made in 50 infants (GA 27 (26-29) weeks), 17 received CPAP and 33 PPV. SpO2 increased rapidly in the first minute after FiO2 1.0 and remained stable. The duration of FiO2 1.0 tended to be shorter in the CPAP group than in the PPV group (CPAP vs. PPV: 65 (33-105) vs. 100 (40-280) s; p = 0.05), SpO2 >95% occurred more often in PPV group (53% vs. 69%) and lasted longer (70(40-95) vs. 120(50-202) s). In CPAP group, minute volume increased from 134 (76-265) mL/kg/min 1 minute before to 240 (157-370) mL/kg/min (pConclusionIn preterm infants at birth, a rapid increase in oxygenation, resulting from a transient increase to 100% oxygen might improve respiratory drive, but increases the risk for hyperoxia.